Abstract
Background: Defective folding and trafficking of β-cell ATP-sensitive potassium (KATP) channels causes congenital hyperinsulinism. Results: Carbamazepine improves the processing and surface expression of trafficking-impaired KATP channels harboring a subset of sulfonylurea receptor 1 mutations. Conclusion: Carbamazepine is a novel corrector of KATP channels. Significance: Carbamazepine may be used to treat congenital hyperinsulinism caused by defective KATPchannel trafficking.
Original language | English |
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Pages (from-to) | 20942-20954 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 29 |
DOIs | |
Publication status | Published - 2013 Jul 19 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology