TY - JOUR
T1 - Carbazole alkaloids from Clausena excavata and their biological activity
AU - Wu, Tian Shung
AU - Huang, Shiow Chyn
AU - Wu, Pei Lin
AU - Teng, Che Ming
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1996/9
Y1 - 1996/9
N2 - Five new carbazole alkaloids, clausines B, E, H, I and K, as well as 22 known compounds, were isolated from the stem bark of Clausena excavata. The structures were established from spectral data and chemical transformation. These compounds showed significant inhibition of rabbit platelet aggregation and caused vasocontraction. The crude methanol extract, partitioned layers and chromatographic fractions revealed the presence of promotive and inhibitive constituents, simultaneously. These results might explain the philosophy of use in Chinese medicine, in that the dose and content variation in a prescription produced different, promotive or inhibitive, effects on therapy.
AB - Five new carbazole alkaloids, clausines B, E, H, I and K, as well as 22 known compounds, were isolated from the stem bark of Clausena excavata. The structures were established from spectral data and chemical transformation. These compounds showed significant inhibition of rabbit platelet aggregation and caused vasocontraction. The crude methanol extract, partitioned layers and chromatographic fractions revealed the presence of promotive and inhibitive constituents, simultaneously. These results might explain the philosophy of use in Chinese medicine, in that the dose and content variation in a prescription produced different, promotive or inhibitive, effects on therapy.
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U2 - 10.1016/0031-9422(96)00212-9
DO - 10.1016/0031-9422(96)00212-9
M3 - Article
C2 - 8987508
AN - SCOPUS:0030239222
SN - 0031-9422
VL - 43
SP - 133
EP - 140
JO - Phytochemistry
JF - Phytochemistry
IS - 1
ER -