Cardiac glycosides from antiaris toxicaria with potent cardiotonic activity

Li Shian Shi, Yu Ren Liao, Ming Jai Su, An Sheng Lee, Ping Chung Kuo, Amooru G. Damu, Sheng Chu Kuo, Han Dong Sun, Kuo Hsiung Lee, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

An ethanolic extract of Antiaris toxicaria trunk bark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Bioassay-guided fractionation of the extract led to identification of nine new cardiac glycosides (1-9, named antiarosides A-I), antiarotoxinin A (10), and 18 known compounds. Their structures were established using MS and NMR spectroscopic studies, including homonuclear and heteronuclear correlation experiments. The ability of these cardiotonic compounds to produce positive inotropic action and their safety indexes were examined in comparison with those of ouabain, a classical inhibitor of Na+/K+-ATPase. Malayoside (23) was nearly equipotent and had a similar safety index to ouabain in guinea pig atria. However, the maximal positive inotropic effect and safety index of 23 in papillary muscle were better than those of ouabain. An electrophysiological recording showed that 23 inhibited the sodium pump current in a concentration-dependent manner.

Original languageEnglish
Pages (from-to)1214-1222
Number of pages9
JournalJournal of Natural Products
Volume73
Issue number7
DOIs
Publication statusPublished - 2010 Jul 23

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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