Cardiopulmonary profile in streptozotocin-induced type 1 diabetic rats during systemic endotoxemia

Ching-Hsia Hung, Che Ning Chang, Yu Wen Chen, Yu Chung Chen, Jann Inn Tzeng, Jhi Joung Wang

Research output: Contribution to journalArticle

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Abstract

This study was designed to determine the severity of cardiopulmonary dysfunction during systemic endotoxemia in type 1 diabetes. Thirty-two adult male Wistar rats were randomly assigned to a control group or to a group treated with streptozotocin (STZ) to create an animal model of type 1 diabetes. Survival time and cardiovascular parameters were continually monitored in urethane anaesthetized animals receiving intravenous infusion of endotoxin (lipopolysaccharide (LPS)) or saline. We also determined arterial blood gases, lung injury, and tumor necrosis factor-alpha (TNF-α) levels in serum and bronchoalveolar lavage fluid. Before LPS administration, the mean arterial pressure in STZ rats was significantly higher than that in normal rats. After LPS injection, the heart rate drop significantly in STZ rats than that in the control group. Also, the increased levels of TNF-α in serum and lavage fluid after LPS treatment were significantly higher in STZ rats than those in normal rats. Survival time in STZ rats was shorter than that in normal rats after LPS application. Albumin content, wet/dry weight ratio of lung, and lung injury were indistinguishable between STZ and normal rats. These results indicate that the cardiopulmonary change which occurs during LPS-induced endotoxemia is minor in STZ-induced diabetic rats.

Original languageEnglish
Article number494179
JournalJournal of Diabetes Research
Volume2013
DOIs
Publication statusPublished - 2013 Jul 1

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Endotoxemia
Streptozocin
Lipopolysaccharides
Lung Injury
Type 1 Diabetes Mellitus
Tumor Necrosis Factor-alpha
Control Groups
Therapeutic Irrigation
Urethane
Bronchoalveolar Lavage Fluid
Serum
Intravenous Infusions
Endotoxins
Wistar Rats
Albumins
Arterial Pressure
Animal Models
Heart Rate
Gases
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Hung, Ching-Hsia ; Chang, Che Ning ; Chen, Yu Wen ; Chen, Yu Chung ; Tzeng, Jann Inn ; Wang, Jhi Joung. / Cardiopulmonary profile in streptozotocin-induced type 1 diabetic rats during systemic endotoxemia. In: Journal of Diabetes Research. 2013 ; Vol. 2013.
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Cardiopulmonary profile in streptozotocin-induced type 1 diabetic rats during systemic endotoxemia. / Hung, Ching-Hsia; Chang, Che Ning; Chen, Yu Wen; Chen, Yu Chung; Tzeng, Jann Inn; Wang, Jhi Joung.

In: Journal of Diabetes Research, Vol. 2013, 494179, 01.07.2013.

Research output: Contribution to journalArticle

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