Cardiotrophin-1 is associated with increased risk of arterial stiffness

Hao Chang Hung; Feng Hwa Lu; Horng Yih Ou; Hung Tsung Wu; Jin Shang Wu; Yi Ching Yang; Chih Jen Chang

doi:10.2217/BMM.14.87

Cardiotrophin-1 is associated with increased risk of arterial stiffness

Hao Chang Hung, Feng Hwa Lu, Horng Yih Ou, Hung Tsung Wu, Jin Shang Wu, Yi Ching Yang, Chih Jen Chang

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

Original language	English
Pages (from-to)	123-130
Number of pages	8
Journal	Biomarkers in Medicine
Volume	9
Issue number	2
DOIs	https://doi.org/10.2217/BMM.14.87
Publication status	Published - 2015 Feb 1

All Science Journal Classification (ASJC) codes

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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title = "Cardiotrophin-1 is associated with increased risk of arterial stiffness",

abstract = "Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.",

author = "Hung, {Hao Chang} and Lu, {Feng Hwa} and Ou, {Horng Yih} and Wu, {Hung Tsung} and Wu, {Jin Shang} and Yang, {Yi Ching} and Chang, {Chih Jen}",

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doi = "10.2217/BMM.14.87",

language = "English",

volume = "9",

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T1 - Cardiotrophin-1 is associated with increased risk of arterial stiffness

AU - Hung, Hao Chang

AU - Lu, Feng Hwa

AU - Ou, Horng Yih

AU - Wu, Hung Tsung

AU - Wu, Jin Shang

AU - Yang, Yi Ching

AU - Chang, Chih Jen

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

AB - Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

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Cardiotrophin-1 is associated with increased risk of arterial stiffness

Abstract

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UN SDGs

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