Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals

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Abstract

Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta =-338.718, 95% CI =-552.786 ∼-124.651, p < 0.01), obese (beta =-530.275, 95% CI =-832.967 ∼-227.583, p < 0.01), and smoking (beta =-377.375, 95% CI =-654.353 ∼-100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

Original languageEnglish
Article number17438
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Dec 1

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Obesity
Weights and Measures
cardiotrophin 1
Lipid Metabolism
Hyperglycemia
Alcohol Drinking
HDL Cholesterol
Epidemiologic Studies
Linear Models
Triglycerides
Homeostasis
Smoking
Regression Analysis
Hypertension
Glucose
Serum
Population

All Science Journal Classification (ASJC) codes

  • General

Cite this

@article{c13ee5a2cb3a4090b143a43df764afbf,
title = "Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals",
abstract = "Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta =-338.718, 95{\%} CI =-552.786 ∼-124.651, p < 0.01), obese (beta =-530.275, 95{\%} CI =-832.967 ∼-227.583, p < 0.01), and smoking (beta =-377.375, 95{\%} CI =-654.353 ∼-100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.",
author = "Hao-Chang Hung and Feng-Hwa Lu and Wu, {Hung Tsung} and Horng-Yih Ou and Yi-Ching Yang and Jin-Shang Wu and Chih-Jen Chang",
year = "2015",
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day = "1",
doi = "10.1038/srep17438",
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T1 - Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals

AU - Hung, Hao-Chang

AU - Lu, Feng-Hwa

AU - Wu, Hung Tsung

AU - Ou, Horng-Yih

AU - Yang, Yi-Ching

AU - Wu, Jin-Shang

AU - Chang, Chih-Jen

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta =-338.718, 95% CI =-552.786 ∼-124.651, p < 0.01), obese (beta =-530.275, 95% CI =-832.967 ∼-227.583, p < 0.01), and smoking (beta =-377.375, 95% CI =-654.353 ∼-100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

AB - Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta =-338.718, 95% CI =-552.786 ∼-124.651, p < 0.01), obese (beta =-530.275, 95% CI =-832.967 ∼-227.583, p < 0.01), and smoking (beta =-377.375, 95% CI =-654.353 ∼-100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

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