Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae

Shin Jong Huang, Chih Ming Kuo, Ying Chih Lin, Yi-Min Chen, Chung Kuang Lu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

Original languageEnglish
Pages (from-to)2512-2515
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number21
DOIs
Publication statusPublished - 2009 May 27

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Dinoflagellida
Aspergillus niger
Aspergillus
Lethal Dose 50
Ketones
Hydroxyl Radical
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Huang, Shin Jong ; Kuo, Chih Ming ; Lin, Ying Chih ; Chen, Yi-Min ; Lu, Chung Kuang. / Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae. In: Tetrahedron Letters. 2009 ; Vol. 50, No. 21. pp. 2512-2515.
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Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae. / Huang, Shin Jong; Kuo, Chih Ming; Lin, Ying Chih; Chen, Yi-Min; Lu, Chung Kuang.

In: Tetrahedron Letters, Vol. 50, No. 21, 27.05.2009, p. 2512-2515.

Research output: Contribution to journalArticle

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AU - Lu, Chung Kuang

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