Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae

Shin Jong Huang; Chih Ming Kuo; Ying Chih Lin; Yi Min Chen; Chung Kuang Lu

doi:10.1016/j.tetlet.2009.03.065

Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae

Shin Jong Huang, Chih Ming Kuo, Ying Chih Lin, Yi Min Chen, Chung Kuang Lu

Department of Biotechnology and Bioindustry Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Carteraol E (1), C₇₄H₁₂₆O₂₄, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD₅₀ value of 0.28 μM, and antifungal activity against Aspergillus niger.

Original language	English
Pages (from-to)	2512-2515
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	21
DOIs	https://doi.org/10.1016/j.tetlet.2009.03.065
Publication status	Published - 2009 May 27

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.03.065

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title = "Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae",

abstract = "Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.",

author = "Huang, {Shin Jong} and Kuo, {Chih Ming} and Lin, {Ying Chih} and Chen, {Yi Min} and Lu, {Chung Kuang}",

note = "Funding Information: Financial support of this project was provided by National Museum of Marine Biology & Aquarium and National Science Council of Taiwan (NSC97-2113-M-291-001). The NMR and ESIMS spectra were obtained at Instrument Centers of National Taiwan University and at core facility of National Museum of Marine Biology & Aquarium. The assistance of Mrs. Shoou-ling Huang and Mrs. Shu-Yun Sun is gratefully appreciated.",

year = "2009",

month = may,

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doi = "10.1016/j.tetlet.2009.03.065",

language = "English",

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pages = "2512--2515",

journal = "Tetrahedron Letters",

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AU - Huang, Shin Jong

AU - Kuo, Chih Ming

AU - Lin, Ying Chih

AU - Chen, Yi Min

AU - Lu, Chung Kuang

N1 - Funding Information: Financial support of this project was provided by National Museum of Marine Biology & Aquarium and National Science Council of Taiwan (NSC97-2113-M-291-001). The NMR and ESIMS spectra were obtained at Instrument Centers of National Taiwan University and at core facility of National Museum of Marine Biology & Aquarium. The assistance of Mrs. Shoou-ling Huang and Mrs. Shu-Yun Sun is gratefully appreciated.

PY - 2009/5/27

Y1 - 2009/5/27

N2 - Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

AB - Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

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DO - 10.1016/j.tetlet.2009.03.065

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae

Abstract

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