Cell response to electrospun PVA and PVA/chitosan nanofibers

J. I. Liang, H. C. Hsu, Y. H. Nien, Fong-chin Su, H. W. Wu, J. P. Chen, Ming-Long Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

PVA and chitosan have been used for many tissue engineering applications. However, most of the studies use only single polymer to fabricate nanofibers. Therefore, the purpose of this study is to fabricate PVA and PVA/Chitosan nanofiber scaffold for potential tissue engineering applications. The nanofrous scaffold was produced via electrospinning. NIH 3T3 fibroblast cells were seeded onto scaffolds for different time points. The attached fibroblast cells appeared round shape on the PVA nanofiber scaffold and spindle shape on the PVA/Chitosan nanofiber scaffold. The result shows that the fibroblast exhibit good cell viability and gene expression on the PVA/Chitosan nanofiber scaffold. Therefore, PVA/Chitosan nanofiber scaffold could be the better choice for further applications.

Original languageEnglish
Title of host publicationNEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
DOIs
Publication statusPublished - 2009 Sep 21
EventIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
Duration: 2009 Apr 32009 Apr 5

Publication series

NameBioengineering, Proceedings of the Northeast Conference
ISSN (Print)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
CountryUnited States
CityBoston, MA
Period09-04-0309-04-05

Fingerprint

Chitosan
Nanofibers
Scaffolds
Fibroblasts
Cells
Scaffolds (biology)
Tissue engineering
Bioelectric potentials
Electrospinning
Gene expression
Polymers

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Liang, J. I., Hsu, H. C., Nien, Y. H., Su, F., Wu, H. W., Chen, J. P., & Yeh, M-L. (2009). Cell response to electrospun PVA and PVA/chitosan nanofibers. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference [4967779] (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967779
Liang, J. I. ; Hsu, H. C. ; Nien, Y. H. ; Su, Fong-chin ; Wu, H. W. ; Chen, J. P. ; Yeh, Ming-Long. / Cell response to electrospun PVA and PVA/chitosan nanofibers. NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. (Bioengineering, Proceedings of the Northeast Conference).
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Liang, JI, Hsu, HC, Nien, YH, Su, F, Wu, HW, Chen, JP & Yeh, M-L 2009, Cell response to electrospun PVA and PVA/chitosan nanofibers. in NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference., 4967779, Bioengineering, Proceedings of the Northeast Conference, IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009, Boston, MA, United States, 09-04-03. https://doi.org/10.1109/NEBC.2009.4967779

Cell response to electrospun PVA and PVA/chitosan nanofibers. / Liang, J. I.; Hsu, H. C.; Nien, Y. H.; Su, Fong-chin; Wu, H. W.; Chen, J. P.; Yeh, Ming-Long.

NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967779 (Bioengineering, Proceedings of the Northeast Conference).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Liang, J. I.

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AU - Yeh, Ming-Long

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AB - PVA and chitosan have been used for many tissue engineering applications. However, most of the studies use only single polymer to fabricate nanofibers. Therefore, the purpose of this study is to fabricate PVA and PVA/Chitosan nanofiber scaffold for potential tissue engineering applications. The nanofrous scaffold was produced via electrospinning. NIH 3T3 fibroblast cells were seeded onto scaffolds for different time points. The attached fibroblast cells appeared round shape on the PVA nanofiber scaffold and spindle shape on the PVA/Chitosan nanofiber scaffold. The result shows that the fibroblast exhibit good cell viability and gene expression on the PVA/Chitosan nanofiber scaffold. Therefore, PVA/Chitosan nanofiber scaffold could be the better choice for further applications.

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Liang JI, Hsu HC, Nien YH, Su F, Wu HW, Chen JP et al. Cell response to electrospun PVA and PVA/chitosan nanofibers. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967779. (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967779