Cells anchored upon a thin organic film with different nano-mechanical properties

Chih Ling Huang, Chia Wei Chang, Jiunn-Der Liao, Yi Te Wu, Ming-Shaung Ju, Chou-Ching Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

By applying dynamic contact module and particular measurement of phase angles, harmonic contact stiffness (S) along with the measured displacement (D) of different self-assembled monolayers (SAMs) adsorbed on Au can be distinguished. The relatively ordered and hydrophobic ODT and DDT molecules adsorbed on Au form high contact stiffness, which are presumably unfavorable substrates for a cell to adhere upon. Short-chain MUA molecules adsorbed on Au provides a hydrophilic characteristic with a relatively low contact stiffness, which may significantly promote cell adhesion. It is, therefore, estimated that the behavior of a cell adhered on SAMs/Au is correlated not only with their outermost chemical species but also with a proper dS/dD matrix acting as a cushion.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalApplied Surface Science
Volume255
Issue number2
DOIs
Publication statusPublished - 2008 Nov 15

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Stiffness
Self assembled monolayers
Mechanical properties
Molecules
DDT
Cell adhesion
Cells
Substrates

All Science Journal Classification (ASJC) codes

  • Surfaces, Coatings and Films

Cite this

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abstract = "By applying dynamic contact module and particular measurement of phase angles, harmonic contact stiffness (S) along with the measured displacement (D) of different self-assembled monolayers (SAMs) adsorbed on Au can be distinguished. The relatively ordered and hydrophobic ODT and DDT molecules adsorbed on Au form high contact stiffness, which are presumably unfavorable substrates for a cell to adhere upon. Short-chain MUA molecules adsorbed on Au provides a hydrophilic characteristic with a relatively low contact stiffness, which may significantly promote cell adhesion. It is, therefore, estimated that the behavior of a cell adhered on SAMs/Au is correlated not only with their outermost chemical species but also with a proper dS/dD matrix acting as a cushion.",
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Cells anchored upon a thin organic film with different nano-mechanical properties. / Huang, Chih Ling; Chang, Chia Wei; Liao, Jiunn-Der; Wu, Yi Te; Ju, Ming-Shaung; Lin, Chou-Ching.

In: Applied Surface Science, Vol. 255, No. 2, 15.11.2008, p. 301-303.

Research output: Contribution to journalArticle

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AU - Huang, Chih Ling

AU - Chang, Chia Wei

AU - Liao, Jiunn-Der

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AU - Lin, Chou-Ching

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