Cellular ability to sense spatial gradients in the presence of multiple competitive ligands

Shu Hao Liou; Chia Chu Chen

doi:10.1103/PhysRevE.85.011904

Cellular ability to sense spatial gradients in the presence of multiple competitive ligands

Shu Hao Liou, Chia Chu Chen

Department of Physics

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Many eukaryotic and prokaryotic cells can exhibit remarkable sensing ability under small gradients of chemical compounds. In this study, we approach this phenomenon by considering the contribution of multiple ligands to the chemical kinetics within the Michaelis-Menten model. This work was inspired by the recent theoretical findings of Hu. Our treatment with practical binding energies and chemical potentials provides results that are consistent with experimental observations.

Original language	English
Article number	011904
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	85
Issue number	1
DOIs	https://doi.org/10.1103/PhysRevE.85.011904
Publication status	Published - 2012 Jan 6

All Science Journal Classification (ASJC) codes

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

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abstract = "Many eukaryotic and prokaryotic cells can exhibit remarkable sensing ability under small gradients of chemical compounds. In this study, we approach this phenomenon by considering the contribution of multiple ligands to the chemical kinetics within the Michaelis-Menten model. This work was inspired by the recent theoretical findings of Hu. Our treatment with practical binding energies and chemical potentials provides results that are consistent with experimental observations.",

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