Challenges and opportunity of recent genome editing and multi-omics in cyanobacteria and microalgae for biorefinery

Way Rong Lin, Shih I. Tan, Chuan Chieh Hsiang, Po Kuei Sung, I-Son Ng

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Microalgae and cyanobacteria are easy to culture, with higher growth rates and photosynthetic efficiencies compared to terrestrial plants, and thus generating higher productivity. The concept of microalgal biorefinery is to assimilate carbon dioxide and convert it to chemical energy/value-added products, such as vitamins, carotenoids, fatty acids, proteins and nucleic acids, to be applied in bioenergy, health foods, aquaculture feed, pharmaceutical and medical fields. Therefore, microalgae are annotated as the third generation feedstock in bioenergy and biorefinery. In past decades, many studies thrived to improve the carbon sequestration efficiency as well as enhance value-added compounds from different algae, especially via genetic engineering, synthetic biology, metabolic design and regulation. From the traditional Agrobacterium-mediated transformation DNA to novel CRISPR (clustered regularly interspaced short palindromic repeats) technology applied in microalgae and cyanobacteria, this review has highlighted the genome editing technology for biorefinery that is a highly environmental friendly trend to sustainable and renewable development.

Original languageEnglish
Article number121932
JournalBioresource technology
Volume291
DOIs
Publication statusPublished - 2019 Nov 1

Fingerprint

bioenergy
cyanobacterium
Clustered Regularly Interspaced Short Palindromic Repeats
genome
Genes
Genetic engineering
Aquaculture
genetic engineering
Vitamins
Nucleic acids
nucleic acid
Carotenoids
Algae
carotenoid
vitamin
Fatty acids
Carbon Dioxide
carbon sequestration
Drug products
Feedstocks

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

Cite this

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abstract = "Microalgae and cyanobacteria are easy to culture, with higher growth rates and photosynthetic efficiencies compared to terrestrial plants, and thus generating higher productivity. The concept of microalgal biorefinery is to assimilate carbon dioxide and convert it to chemical energy/value-added products, such as vitamins, carotenoids, fatty acids, proteins and nucleic acids, to be applied in bioenergy, health foods, aquaculture feed, pharmaceutical and medical fields. Therefore, microalgae are annotated as the third generation feedstock in bioenergy and biorefinery. In past decades, many studies thrived to improve the carbon sequestration efficiency as well as enhance value-added compounds from different algae, especially via genetic engineering, synthetic biology, metabolic design and regulation. From the traditional Agrobacterium-mediated transformation DNA to novel CRISPR (clustered regularly interspaced short palindromic repeats) technology applied in microalgae and cyanobacteria, this review has highlighted the genome editing technology for biorefinery that is a highly environmental friendly trend to sustainable and renewable development.",
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Challenges and opportunity of recent genome editing and multi-omics in cyanobacteria and microalgae for biorefinery. / Lin, Way Rong; Tan, Shih I.; Hsiang, Chuan Chieh; Sung, Po Kuei; Ng, I-Son.

In: Bioresource technology, Vol. 291, 121932, 01.11.2019.

Research output: Contribution to journalReview article

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AU - Lin, Way Rong

AU - Tan, Shih I.

AU - Hsiang, Chuan Chieh

AU - Sung, Po Kuei

AU - Ng, I-Son

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