Characteristics and bioactivity of CaP porous coating with bio-inspired dopamine

Yen Ting Liu, Kuan Chen Kung, Tzer Min Lee, Truan Sheng Lui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Implants made of titanium and its alloys are widely used in dental and orthopedic fields due to their excellent chemical stability and mechanical properties. However, due to the bio-inert properties of titanium and its alloys, it is difficult to achieve a chemical bond with bone tissue and to form a new bond on the surface. To improve biocompatibility, surface treatments are often used to modify the chemical and morphological properties. Besides, the mussel-inspired molecule of 3,4-dihydroxy-L-phenylalanine (dopamine) shows excellent biological responses. The aim of this study is to investigate the physicochemical and biomedical properties of CaP porous coating with dopamine. The CaP porous coating was prepared on titanium by micro-arc oxidation, and then bio-inspired molecular of dopamine modified surface to improve the cell behavior. Characteristics of the morphology, chemical composition, and interfacial properties of dopamine-functionalized CaP porous architecture was performed by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The osteoblastic cell behaviour, such as differentiation and morphology is evaluated. The nitrogen signal in XPS spectrum was indicated that the dopamine existed in the porous coating. The anatase and rutile phases of porous coating with dopamine were identified. Morphologies of porous coating with dopamine showed the uniform and three-dimensional structure. Cell culture experiments demonstrate that the porous coating with dopamine would improve cell behavior. All findings in this study indicated that CaP porous coating with dopamine have good bioactivity for clinical applications.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages233-236
Number of pages4
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - 2013 Jan 1
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 2012 Oct 212012 Oct 24

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period12-10-2112-10-24

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Characteristics and bioactivity of CaP porous coating with bio-inspired dopamine'. Together they form a unique fingerprint.

Cite this