Characterization of aging-associated cardiac diastolic dysfunction

Wei Ting Chang, Jung San Chen, Yung Kung Hung, Wei Chuan Tsai, Jer Nan Juang, Ping Yen Liu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aims: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between e/e′ and wedge pressure. Methods and Results: We enrolled 919 patients (male: 52.6%[484/919]). Compared with the younger population of controls (mean age: 43.9±11.7 years; n=211; male: 62.1% [131/211]), the elderly (mean age: 76.3±6.2; n=708; male: 52.6% [484/708]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all p<0.05). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly (e′: 0.09±0.02 vs. 0.08±0.02; p=0.02) and corresponded to the higher estimated wedge (e/e′) pressure (7.76±2.44 vs. 8.35±2.64; p=0.02) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with e/e′ values >9. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts. Conclusion: Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.

Original languageEnglish
Article numbere97455
JournalPloS one
Volume9
Issue number5
DOIs
Publication statusPublished - 2014 May 28

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myocardium
Myocardium
Aging of materials
heart failure
Theoretical Models
mathematical models
Geriatrics
heart
Stiffness
Diastolic Heart Failure
Mathematical models
Pulmonary Wedge Pressure
Population Control
Ventricular Pressure
Medical problems
diabetes mellitus
health status
Individuality
hypertension
Health Status

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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title = "Characterization of aging-associated cardiac diastolic dysfunction",
abstract = "Aims: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between e/e′ and wedge pressure. Methods and Results: We enrolled 919 patients (male: 52.6{\%}[484/919]). Compared with the younger population of controls (mean age: 43.9±11.7 years; n=211; male: 62.1{\%} [131/211]), the elderly (mean age: 76.3±6.2; n=708; male: 52.6{\%} [484/708]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all p<0.05). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly (e′: 0.09±0.02 vs. 0.08±0.02; p=0.02) and corresponded to the higher estimated wedge (e/e′) pressure (7.76±2.44 vs. 8.35±2.64; p=0.02) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with e/e′ values >9. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts. Conclusion: Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.",
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Characterization of aging-associated cardiac diastolic dysfunction. / Chang, Wei Ting; Chen, Jung San; Hung, Yung Kung; Tsai, Wei Chuan; Juang, Jer Nan; Liu, Ping Yen.

In: PloS one, Vol. 9, No. 5, e97455, 28.05.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characterization of aging-associated cardiac diastolic dysfunction

AU - Chang, Wei Ting

AU - Chen, Jung San

AU - Hung, Yung Kung

AU - Tsai, Wei Chuan

AU - Juang, Jer Nan

AU - Liu, Ping Yen

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N2 - Aims: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between e/e′ and wedge pressure. Methods and Results: We enrolled 919 patients (male: 52.6%[484/919]). Compared with the younger population of controls (mean age: 43.9±11.7 years; n=211; male: 62.1% [131/211]), the elderly (mean age: 76.3±6.2; n=708; male: 52.6% [484/708]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all p<0.05). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly (e′: 0.09±0.02 vs. 0.08±0.02; p=0.02) and corresponded to the higher estimated wedge (e/e′) pressure (7.76±2.44 vs. 8.35±2.64; p=0.02) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with e/e′ values >9. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts. Conclusion: Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.

AB - Aims: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between e/e′ and wedge pressure. Methods and Results: We enrolled 919 patients (male: 52.6%[484/919]). Compared with the younger population of controls (mean age: 43.9±11.7 years; n=211; male: 62.1% [131/211]), the elderly (mean age: 76.3±6.2; n=708; male: 52.6% [484/708]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all p<0.05). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly (e′: 0.09±0.02 vs. 0.08±0.02; p=0.02) and corresponded to the higher estimated wedge (e/e′) pressure (7.76±2.44 vs. 8.35±2.64; p=0.02) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with e/e′ values >9. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts. Conclusion: Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.

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