Characterization of blood cell dynamics in micro-channel flows

Hsin Yi Lai, Chao Kuang Chen, Yuh Ling Chang

Research output: Contribution to journalArticle

Abstract

This paper characterizes the dynamic behaviour of a two-dimensional red blood cell (RBC) in micro-channel flows by using a smooth particle hydrodynamics (SPH) model. In the model, the RBC membrane is represented by membrane particles that are connected to neighbouring membrane particles by linear springs. The plasma and cytoplasm are modelled as incompressible homogeneous Newtonian fluids, represented by SPH particles. In order to verify the model, the deformation of a RBC in capillary, with the RBC moving downstream and possessing a characteristic parachute shape in steady state, is characterized. The effect of various system parameters on the RBC deformation are also investigated, which include spring modulus, density and viscosity ratios of the fluid to RBC. The dynamic behaviour of the RBC entering a contraction micro-channel, two wings are folded toward each other. The bending of the membrane is increased and the travelling time increases as the spring modulus is. increased. The results are in good agreement with those previously reported.

Original languageEnglish
Pages (from-to)469-475
Number of pages7
JournalJournal of the Chinese Society of Mechanical Engineers, Transactions of the Chinese Institute of Engineers, Series C/Chung-Kuo Chi Hsueh Kung Ch'eng Hsuebo Pao
Volume35
Issue number6
Publication statusPublished - 2014 Dec 1

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

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