Characterization of Cytochalasins and Steroids from the Ascomycete Daldinia concentrica and Their Cytotoxicity

Hoang Van Trung, Ping Chung Kuo, Nguyen Ngoc Tuan, Nguyen Thi Ngan, Nguyen Quang Trung, Nguyen Tan Thanh, Ha Viet Hai, Doan Lan Phuong, Bach Long Giang, Yue Chiun Li, Tian Shung Wu, Tran Dinh Thang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

One new cytochalasin daldinin (1), 2 known cytochalasins 2 and 3, along with 2 steroids 4 and 5, were characterized from the methanol extracts of the fruiting bodies of Daldinia concentrica. The structure of new compound 1 was elucidated using a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectrometric analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumor cell lines and the tested compounds demonstrated moderate-to-weak cytotoxicity.

Original languageEnglish
JournalNatural Product Communications
Volume14
Issue number5
DOIs
Publication statusPublished - 2019 May

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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