Characterization of Cytochalasins and Steroids from the Ascomycete Daldinia concentrica and Their Cytotoxicity

Hoang Van Trung, Ping Chung Kuo, Nguyen Ngoc Tuan, Nguyen Thi Ngan, Nguyen Quang Trung, Nguyen Tan Thanh, Ha Viet Hai, Doan Lan Phuong, Bach Long Giang, Yue Chiun Li, Tian Shung Wu, Tran Dinh Thang

Research output: Contribution to journalArticle

Abstract

One new cytochalasin daldinin (1), 2 known cytochalasins 2 and 3, along with 2 steroids 4 and 5, were characterized from the methanol extracts of the fruiting bodies of Daldinia concentrica. The structure of new compound 1 was elucidated using a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectrometric analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumor cell lines and the tested compounds demonstrated moderate-to-weak cytotoxicity.

Original languageEnglish
JournalNatural Product Communications
Volume14
Issue number5
DOIs
Publication statusPublished - 2019 May

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Cytochalasins
cytochalasins
Ascomycota
steroids
cytotoxicity
Steroids
fruiting bodies
Tumor Cell Line
ionization
Methanol
nuclear magnetic resonance spectroscopy
methanol
Magnetic Resonance Spectroscopy
cell lines
extracts
neoplasm cells

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Van Trung, Hoang ; Kuo, Ping Chung ; Tuan, Nguyen Ngoc ; Ngan, Nguyen Thi ; Trung, Nguyen Quang ; Thanh, Nguyen Tan ; Hai, Ha Viet ; Phuong, Doan Lan ; Giang, Bach Long ; Li, Yue Chiun ; Wu, Tian Shung ; Thang, Tran Dinh. / Characterization of Cytochalasins and Steroids from the Ascomycete Daldinia concentrica and Their Cytotoxicity. In: Natural Product Communications. 2019 ; Vol. 14, No. 5.
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abstract = "One new cytochalasin daldinin (1), 2 known cytochalasins 2 and 3, along with 2 steroids 4 and 5, were characterized from the methanol extracts of the fruiting bodies of Daldinia concentrica. The structure of new compound 1 was elucidated using a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectrometric analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumor cell lines and the tested compounds demonstrated moderate-to-weak cytotoxicity.",
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Van Trung, H, Kuo, PC, Tuan, NN, Ngan, NT, Trung, NQ, Thanh, NT, Hai, HV, Phuong, DL, Giang, BL, Li, YC, Wu, TS & Thang, TD 2019, 'Characterization of Cytochalasins and Steroids from the Ascomycete Daldinia concentrica and Their Cytotoxicity', Natural Product Communications, vol. 14, no. 5. https://doi.org/10.1177/1934578X19846320

Characterization of Cytochalasins and Steroids from the Ascomycete Daldinia concentrica and Their Cytotoxicity. / Van Trung, Hoang; Kuo, Ping Chung; Tuan, Nguyen Ngoc; Ngan, Nguyen Thi; Trung, Nguyen Quang; Thanh, Nguyen Tan; Hai, Ha Viet; Phuong, Doan Lan; Giang, Bach Long; Li, Yue Chiun; Wu, Tian Shung; Thang, Tran Dinh.

In: Natural Product Communications, Vol. 14, No. 5, 05.2019.

Research output: Contribution to journalArticle

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AU - Ngan, Nguyen Thi

AU - Trung, Nguyen Quang

AU - Thanh, Nguyen Tan

AU - Hai, Ha Viet

AU - Phuong, Doan Lan

AU - Giang, Bach Long

AU - Li, Yue Chiun

AU - Wu, Tian Shung

AU - Thang, Tran Dinh

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