Characterization of iron core-gold shell nanoparticles for anti-cancer treatments: Chemical and structural transformations during storage and use

Ya Na Wu, Dar Bin Shieh, Li Xing Yang, Hwo Shuenn Sheu, Rongkun Zheng, Pall Thordarson, Dong Hwang Chen, Filip Braet

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.

Original languageEnglish
Article number2572
JournalMaterials
Volume11
Issue number12
DOIs
Publication statusPublished - 2018 Dec 17

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Condensed Matter Physics

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