Abstract
HIV-1 CRF07-BC became prevalent in Taiwan after the epidemic among injection drug users (IDUs). We describe a unique recombinant form (URF) consisting of CRF01-AE and CRF07-BC (named URF-0107-H8) genes detected from an IDU. The 8.8 kb near full-length genome of URF-0107-H8 had a CRF01-AE backbone with two CRF07-BC fragments in the reverse transcriptase and integrase region [RT-Int; HXB2 nucleotide (nt) positions 2942-4709] and within the envelop (nt 8467-8722) gene. Phylogenetic analyses revealed that its 1.8 kb RT-Int sequence clustered with those of CRF07-BC strains from Taiwan, while sequences of CRF01-AE portions were more similar to those of Central African origin than contemporaneous CRF01-AE isolates in Taiwan or prevalent in East or Southeast Asia. Recombination breakpoints and phylogenetic relationships of URF-0107-H8 were different from those of CRF01-AE/CRF07-BC URFs previously reported from China. This highlighted the importance of continual monitoring of genetic evolution of HIV strains and the emergence of new recombinants.
Original language | English |
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Pages (from-to) | 588-594 |
Number of pages | 7 |
Journal | AIDS Research and Human Retroviruses |
Volume | 32 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2016 Jun |
All Science Journal Classification (ASJC) codes
- Immunology
- Virology
- Infectious Diseases