Chemical and antiplatelet aggregative investigation of the leaves of Clausena excavata

Wu Tian-Shung, Huang Shiow-Chyn, Lai Jeng-Shiow, Teng Che-Ming, Ko Feng-Nien, Kuoh Chang-Sheng

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A new carbazole alkaloid, clausine-L together with 11 known compounds, safrole, glutinol, 132-hydroxy(132-R)-pheophytin-a, methyl pheophobide-a, scopoletin, steroidal glycoside [β-sitosteryl glucoside +stigmasteryl glucoside], 2-methoxy-4-(2-propenyl)phenyl-β-d-glucoside, 2,6-dimethoxy-4-(2-propenyl)phenyl-β-d-glucoside, p-hydroxybenzoic acid, rutin and nicotiflorin were isolated and characterized from the leaves of Clausena excavata. Their structures were elucidated by spectroscopic methods and/or chemical transformation. Among them, safrole showed significant antiplatelet aggregative activity which was induced by arachidonic acid and collagen.

Original languageEnglish
Pages (from-to)449-451
Number of pages3
Issue number2
Publication statusPublished - 1993 Jan 20

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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