Chemical constituents from Andrographis echioides and their anti-inflammatory activity

De Yang Shen, Shin Hun Juang, Ping Chung Kuo, Guan Jhong Huang, Yu Yi Chan, Amooru G. Damu, Tian Shung Wu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.

Original languageEnglish
Pages (from-to)496-514
Number of pages19
JournalInternational journal of molecular sciences
Volume14
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Andrographis
Flavonoids
glucosides
spectrum analysis
Anti-Inflammatory Agents
examination
Glycosides
Phytochemicals
Structure-Activity Relationship
Bioactivity
Spectrum analysis

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Shen, De Yang ; Juang, Shin Hun ; Kuo, Ping Chung ; Huang, Guan Jhong ; Chan, Yu Yi ; Damu, Amooru G. ; Wu, Tian Shung. / Chemical constituents from Andrographis echioides and their anti-inflammatory activity. In: International journal of molecular sciences. 2013 ; Vol. 14, No. 1. pp. 496-514.
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Chemical constituents from Andrographis echioides and their anti-inflammatory activity. / Shen, De Yang; Juang, Shin Hun; Kuo, Ping Chung; Huang, Guan Jhong; Chan, Yu Yi; Damu, Amooru G.; Wu, Tian Shung.

In: International journal of molecular sciences, Vol. 14, No. 1, 01.01.2013, p. 496-514.

Research output: Contribution to journalArticle

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