Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities

Ping Chung Kuo, Tsong Long Hwang, Ying Ting Lin, Yuh Chi Kuo, Yann Lii Leu

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC50 of 25.01 ± 6.95 μM, respectively.

Original languageEnglish
Pages (from-to)715-722
Number of pages8
JournalArchives of Pharmacal Research
Volume34
Issue number5
DOIs
Publication statusPublished - 2011 May

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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