TY - JOUR
T1 - Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities
AU - Kuo, Ping Chung
AU - Hwang, Tsong Long
AU - Lin, Ying Ting
AU - Kuo, Yuh Chi
AU - Leu, Yann Lii
N1 - Funding Information:
The authors are thankful to the National Science Council, Taiwan, R. O. C. (NSC 92-2323-B-182-001) for financial support of the present research. We are grateful to the National Center for High-performance Computing for computer time and facilities. We also thank Ms L. N. Lai, National Cheng Kung University, for recording the mass spectra.
PY - 2011/5
Y1 - 2011/5
N2 - In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC50 of 25.01 ± 6.95 μM, respectively.
AB - In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC50 of 25.01 ± 6.95 μM, respectively.
UR - https://www.scopus.com/pages/publications/79960239504
UR - https://www.scopus.com/pages/publications/79960239504#tab=citedBy
U2 - 10.1007/s12272-011-0503-7
DO - 10.1007/s12272-011-0503-7
M3 - Article
C2 - 21656355
AN - SCOPUS:79960239504
SN - 0253-6269
VL - 34
SP - 715
EP - 722
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
IS - 5
ER -