Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

Tran Dinh Thang, Ping Chung Kuo, Nguyen Thi Bich Ngoc, Tsong Long Hwang, Mei Lin Yang, Shih Huang Ta, E. Jian Lee, Dai Huang Kuo, Nguyen Huy Hung, Nguyen Ngoc Tuan, Tian Shung Wu

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Abstract

A chemical investigation of the fruiting bodies of Hexagonia apiaria resulted in the identification of nine compounds including five new triterpenoids, hexagonins A-E (1-5), along with four known compounds. The purified constituents were examined for their anti-inflammatory activity. Among the tested compounds, hexatenuin A displayed the most significant inhibition of superoxide anion generation and elastase release. These triterpenoids may have potentials as anti-inflammatory agents.

Original languageEnglish
Pages (from-to)2552-2558
Number of pages7
JournalJournal of Natural Products
Volume78
Issue number11
DOIs
Publication statusPublished - 2015 Nov 25

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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