Chemical constituents from the leaves of annona reticulata and their inhibitory effects on NO production

Tran Dinh Thang; Ping Chung Kuo; Guan Jhong Huang; Nguyen Huy Hung; Bow Shin Huang; Mei Lin Yang; Ngo Xuan Luong; Tian Shung Wu

doi:10.3390/molecules18044477

Chemical constituents from the leaves of annona reticulata and their inhibitory effects on NO production

Tran Dinh Thang, Ping Chung Kuo, Guan Jhong Huang, Nguyen Huy Hung, Bow Shin Huang, Mei Lin Yang, Ngo Xuan Luong, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC₅₀ values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.

Original language	English
Pages (from-to)	4477-4486
Number of pages	10
Journal	Molecules
Volume	18
Issue number	4
DOIs	https://doi.org/10.3390/molecules18044477
Publication status	Published - 2013 Apr

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.",

author = "Thang, {Tran Dinh} and Kuo, {Ping Chung} and Huang, {Guan Jhong} and Hung, {Nguyen Huy} and Huang, {Bow Shin} and Yang, {Mei Lin} and Luong, {Ngo Xuan} and Wu, {Tian Shung}",

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AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Huang, Guan Jhong

AU - Hung, Nguyen Huy

AU - Huang, Bow Shin

AU - Yang, Mei Lin

AU - Luong, Ngo Xuan

AU - Wu, Tian Shung

PY - 2013/4

Y1 - 2013/4

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AB - In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.

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Chemical constituents from the leaves of annona reticulata and their inhibitory effects on NO production

Abstract

All Science Journal Classification (ASJC) codes

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