Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam, Po Hsun Chen, Hsin Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

Original languageEnglish
Article number2541
JournalMolecules
Volume23
Issue number10
DOIs
Publication statusPublished - 2018 Oct 5

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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