Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam, Po Hsun Chen, Hsin Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

Original languageEnglish
Article number2541
JournalMolecules
Volume23
Issue number10
DOIs
Publication statusPublished - 2018 Oct 5

Fingerprint

Tinospora
N-Formylmethionine Leucyl-Phenylalanine
Lignans
Cytochalasin B
Pyrroles
alkaloids
phenylalanine
inorganic peroxides
Pancreatic Elastase
pyrroles
Bioactivity
stems
Alkaloids
Superoxides
Anti-Inflammatory Agents
anions
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Lam, Sio Hong ; Chen, Po Hsun ; Hung, Hsin Yi ; Hwang, Tsong Long ; Chiang, Chih Chao ; Thang, Tran Dinh ; Kuo, Ping Chung ; Wu, Tian Shung. / Chemical constituents from the stems of tinospora sinensis and their bioactivity. In: Molecules. 2018 ; Vol. 23, No. 10.
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Chemical constituents from the stems of tinospora sinensis and their bioactivity. / Lam, Sio Hong; Chen, Po Hsun; Hung, Hsin Yi; Hwang, Tsong Long; Chiang, Chih Chao; Thang, Tran Dinh; Kuo, Ping Chung; Wu, Tian Shung.

In: Molecules, Vol. 23, No. 10, 2541, 05.10.2018.

Research output: Contribution to journalArticle

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T1 - Chemical constituents from the stems of tinospora sinensis and their bioactivity

AU - Lam, Sio Hong

AU - Chen, Po Hsun

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AU - Hwang, Tsong Long

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AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

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