Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam; Po Hsun Chen; Hsin Yi Hung; Tsong Long Hwang; Chih Chao Chiang; Tran Dinh Thang; Ping Chung Kuo; Tian Shung Wu

doi:10.3390/molecules23102541

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam, Po Hsun Chen, Hsin Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

Original language	English
Article number	2541
Journal	Molecules
Volume	23
Issue number	10
DOIs	https://doi.org/10.3390/molecules23102541
Publication status	Published - 2018 Oct 5

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.3390/molecules23102541

Cite this

@article{b899537645ae45269fb08d490507d661,

title = "Chemical constituents from the stems of tinospora sinensis and their bioactivity",

abstract = "Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.",

author = "Lam, {Sio Hong} and Chen, {Po Hsun} and Hung, {Hsin Yi} and Hwang, {Tsong Long} and Chiang, {Chih Chao} and Thang, {Tran Dinh} and Kuo, {Ping Chung} and Wu, {Tian Shung}",

year = "2018",

month = oct,

day = "5",

doi = "10.3390/molecules23102541",

language = "English",

volume = "23",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

}

TY - JOUR

T1 - Chemical constituents from the stems of tinospora sinensis and their bioactivity

AU - Lam, Sio Hong

AU - Chen, Po Hsun

AU - Hung, Hsin Yi

AU - Hwang, Tsong Long

AU - Chiang, Chih Chao

AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2018/10/5

Y1 - 2018/10/5

N2 - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

AB - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

UR - http://www.scopus.com/inward/record.url?scp=85054530915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054530915&partnerID=8YFLogxK

U2 - 10.3390/molecules23102541

DO - 10.3390/molecules23102541

M3 - Article

C2 - 30301176

AN - SCOPUS:85054530915

SN - 1420-3049

VL - 23

JO - Molecules

JF - Molecules

IS - 10

M1 - 2541

ER -

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this