Chemical constituents of the leaves of glochidion obliquum and their bioactivity

Tran Dinh Thang, Ping Chung Kuo, Chun Shu Yu, Yuh Chiang Shen, Le Thi Mai Hoa, Tran Van Thanh, Yao Haur Kuo, Mei Lin Yang, Tian-Shung Wu

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A new flavonoid glycoside, globlin A (1), and eleven known compounds were isolated from methanolic extracts of the leaves of Glochidion obliquum. The structure of this new compound was established with a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-ESI-MS analyses. Chemical structures of the other known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the isolates were examined for their bioactivities. Among the tested compounds, rotundic acid (4) displayed significant cytotoxicity and anti-inflammatory activities.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalArchives of Pharmacal Research
Volume34
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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