Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin, Tsong Long Hwang, Fu An Chen, Chia Hsin Huang, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

Original languageEnglish
Pages (from-to)1911-1921
Number of pages11
JournalJournal of Natural Products
Volume79
Issue number8
DOIs
Publication statusPublished - 2016 Aug 26

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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