Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer

Ying Chi Chen; Wen Tai Chiu; Chin Chang; Ping Ching Wu; Ting Yuan Tu; Hong Ping Lin; Hsien Chang Chang

doi:10.1039/C8RA08538B

Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer

Ying Chi Chen, Wen Tai Chiu, Chin Chang, Ping Ching Wu, Ting Yuan Tu, Hong Ping Lin, Hsien Chang Chang

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Chemo-photothermal therapy, which exhibits synergistic effects, is more effective than either of the treatments administered alone because of its superior ability to target and destroy cancer cells. An anti-cancer compound (doxorubicin, DOX) was embedded in silica-carbon hollow spheres (SCHSs) using heat and vacuum to integrate multi-therapeutic effects onto one platform and subsequently improve the anti-cancer efficacy. SCHSs were synthesized via a surface activation method and its highly porous surface enhanced the loading content of the desired drug. SCHSs are an infrared photothermal material that can destroy targeted cells by heating under near-infrared (NIR) laser illumination at 808 nm. NIR laser illumination also enhances DOX release from SCHSs to increase the anti-cancer efficiency of DOX-loaded SCHSs (DOX-SCHSs) in both two-dimensional and three-dimensional multicellular tumor spheroid cultures. SCHSs exhibited high heat-generating ability and pH-responsive drug delivery. In conclusion, this study demonstrated that DOX-SCHSs represent a potential tool for chemo-photothermal therapy due to its photothermal effects. Thus, our findings imply that the high cancer cell killing efficiency of DOX-SCHSs induced by NIR illumination can be used for the treatment of tumors.

Original language	English
Pages (from-to)	36775-36784
Number of pages	10
Journal	RSC Advances
Volume	8
Issue number	64
DOIs	https://doi.org/10.1039/C8RA08538B
Publication status	Published - 2018

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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10.1039/C8RA08538B

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title = "Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer",

abstract = "Chemo-photothermal therapy, which exhibits synergistic effects, is more effective than either of the treatments administered alone because of its superior ability to target and destroy cancer cells. An anti-cancer compound (doxorubicin, DOX) was embedded in silica-carbon hollow spheres (SCHSs) using heat and vacuum to integrate multi-therapeutic effects onto one platform and subsequently improve the anti-cancer efficacy. SCHSs were synthesized via a surface activation method and its highly porous surface enhanced the loading content of the desired drug. SCHSs are an infrared photothermal material that can destroy targeted cells by heating under near-infrared (NIR) laser illumination at 808 nm. NIR laser illumination also enhances DOX release from SCHSs to increase the anti-cancer efficiency of DOX-loaded SCHSs (DOX-SCHSs) in both two-dimensional and three-dimensional multicellular tumor spheroid cultures. SCHSs exhibited high heat-generating ability and pH-responsive drug delivery. In conclusion, this study demonstrated that DOX-SCHSs represent a potential tool for chemo-photothermal therapy due to its photothermal effects. Thus, our findings imply that the high cancer cell killing efficiency of DOX-SCHSs induced by NIR illumination can be used for the treatment of tumors.",

author = "Chen, {Ying Chi} and Chiu, {Wen Tai} and Chin Chang and Wu, {Ping Ching} and Tu, {Ting Yuan} and Lin, {Hong Ping} and Chang, {Hsien Chang}",

note = "Funding Information: We thank the “Bio-image Core Facility of the National Core Facilities Program for Biopharmaceuticals, Ministry of Science and Technology, Taiwan” and “Micro/Nano Science and Technology Center” for their technical services. We acknowledge the nancial support provided by the Ministry of Science and Technology of Taiwan under Grant No. MOST 105-2221-E-006-025-MY3 and MOST 105-2628-B-006-003-MY3. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2018",

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T1 - Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer

AU - Chen, Ying Chi

AU - Chiu, Wen Tai

AU - Chang, Chin

AU - Wu, Ping Ching

AU - Tu, Ting Yuan

AU - Lin, Hong Ping

AU - Chang, Hsien Chang

N1 - Funding Information: We thank the “Bio-image Core Facility of the National Core Facilities Program for Biopharmaceuticals, Ministry of Science and Technology, Taiwan” and “Micro/Nano Science and Technology Center” for their technical services. We acknowledge the nancial support provided by the Ministry of Science and Technology of Taiwan under Grant No. MOST 105-2221-E-006-025-MY3 and MOST 105-2628-B-006-003-MY3. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

N2 - Chemo-photothermal therapy, which exhibits synergistic effects, is more effective than either of the treatments administered alone because of its superior ability to target and destroy cancer cells. An anti-cancer compound (doxorubicin, DOX) was embedded in silica-carbon hollow spheres (SCHSs) using heat and vacuum to integrate multi-therapeutic effects onto one platform and subsequently improve the anti-cancer efficacy. SCHSs were synthesized via a surface activation method and its highly porous surface enhanced the loading content of the desired drug. SCHSs are an infrared photothermal material that can destroy targeted cells by heating under near-infrared (NIR) laser illumination at 808 nm. NIR laser illumination also enhances DOX release from SCHSs to increase the anti-cancer efficiency of DOX-loaded SCHSs (DOX-SCHSs) in both two-dimensional and three-dimensional multicellular tumor spheroid cultures. SCHSs exhibited high heat-generating ability and pH-responsive drug delivery. In conclusion, this study demonstrated that DOX-SCHSs represent a potential tool for chemo-photothermal therapy due to its photothermal effects. Thus, our findings imply that the high cancer cell killing efficiency of DOX-SCHSs induced by NIR illumination can be used for the treatment of tumors.

AB - Chemo-photothermal therapy, which exhibits synergistic effects, is more effective than either of the treatments administered alone because of its superior ability to target and destroy cancer cells. An anti-cancer compound (doxorubicin, DOX) was embedded in silica-carbon hollow spheres (SCHSs) using heat and vacuum to integrate multi-therapeutic effects onto one platform and subsequently improve the anti-cancer efficacy. SCHSs were synthesized via a surface activation method and its highly porous surface enhanced the loading content of the desired drug. SCHSs are an infrared photothermal material that can destroy targeted cells by heating under near-infrared (NIR) laser illumination at 808 nm. NIR laser illumination also enhances DOX release from SCHSs to increase the anti-cancer efficiency of DOX-loaded SCHSs (DOX-SCHSs) in both two-dimensional and three-dimensional multicellular tumor spheroid cultures. SCHSs exhibited high heat-generating ability and pH-responsive drug delivery. In conclusion, this study demonstrated that DOX-SCHSs represent a potential tool for chemo-photothermal therapy due to its photothermal effects. Thus, our findings imply that the high cancer cell killing efficiency of DOX-SCHSs induced by NIR illumination can be used for the treatment of tumors.

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Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer

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