Chemopreventative effects of tetrahydrocurcumin on human diseases

Jia Ching Wu, Mei Ling Tsai, Ching Shu Lai, Ying-Jan Wang, Chi Tang Ho, Min Hsiung Pan

Research output: Contribution to journalReview article

35 Citations (Scopus)


Chemoprevention is a relatively new and promising strategy to prevent human degenerative diseases, including cancer, and is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the progress of human diseases. Tetrahydrocurcumin (THC) is a major metabolite of curcumin (extracted from the roots of the Curcuma longa Linn). THC has been demonstrated to prevent oxidative stress and inflammation, to act against neurodegeneration, and to possess anti-cancer activity. In this review, we summarize the current knowledge and underlying molecular mechanisms of the chemopreventative activities of THC and its potential effects on the development of various human diseases.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalFood and Function
Issue number1
Publication statusPublished - 2014 Jan 1


All Science Journal Classification (ASJC) codes

  • Food Science

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