Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture

Chen-Sheng Yeh; P. W. Lin; Yu-Cheng Lin

doi:10.1109/SENSOR.2009.5285485

Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this study, we successfully produced the chitosan microfibers using the proposed various angles of microfluidic chip, which was also been simulated. By controlling the core and sheath flow rates, we were able to generate laminar flow of different diameters from 15 μm to 40 μm. And the diameter of chitosan microfiber was measured from 20 μm to 50 μm. The microchannel of angle 30° could produce chitosan laminar flow of a smaller diameter than the angle 60° and angle 45° at the fixed flow rates. Finally, the chitosan microfiber was chosen as scaffold and the schwann cell and fibroblast cell with chitosan microfibers were used for cell culture to test effect in tissue engineering application.

Original language	English
Title of host publication	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	378-381
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2009.5285485
Publication status	Published - 2009 Dec 11
Event	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States Duration: 2009 Jun 21 → 2009 Jun 25

Publication series

Name	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Country/Territory	United States
City	Denver, CO
Period	09-06-21 → 09-06-25

All Science Journal Classification (ASJC) codes

Hardware and Architecture
Electrical and Electronic Engineering

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10.1109/SENSOR.2009.5285485

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Yeh, C.-S., Lin, P. W., & Lin, Y.-C. (2009). Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 378-381). Article 5285485 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285485

Yeh, Chen-Sheng ; Lin, P. W. ; Lin, Yu-Cheng. / Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture. TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. pp. 378-381 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

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title = "Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture",

abstract = "In this study, we successfully produced the chitosan microfibers using the proposed various angles of microfluidic chip, which was also been simulated. By controlling the core and sheath flow rates, we were able to generate laminar flow of different diameters from 15 μm to 40 μm. And the diameter of chitosan microfiber was measured from 20 μm to 50 μm. The microchannel of angle 30° could produce chitosan laminar flow of a smaller diameter than the angle 60° and angle 45° at the fixed flow rates. Finally, the chitosan microfiber was chosen as scaffold and the schwann cell and fibroblast cell with chitosan microfibers were used for cell culture to test effect in tissue engineering application.",

author = "Chen-Sheng Yeh and Lin, {P. W.} and Yu-Cheng Lin",

year = "2009",

month = dec,

day = "11",

doi = "10.1109/SENSOR.2009.5285485",

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series = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems",

pages = "378--381",

booktitle = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems",

note = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems ; Conference date: 21-06-2009 Through 25-06-2009",

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Yeh, C-S, Lin, PW & Lin, Y-C 2009, Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture. in TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems., 5285485, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 378-381, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, United States, 09-06-21. https://doi.org/10.1109/SENSOR.2009.5285485

Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture. / Yeh, Chen-Sheng; Lin, P. W.; Lin, Yu-Cheng.
TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 378-381 5285485 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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N2 - In this study, we successfully produced the chitosan microfibers using the proposed various angles of microfluidic chip, which was also been simulated. By controlling the core and sheath flow rates, we were able to generate laminar flow of different diameters from 15 μm to 40 μm. And the diameter of chitosan microfiber was measured from 20 μm to 50 μm. The microchannel of angle 30° could produce chitosan laminar flow of a smaller diameter than the angle 60° and angle 45° at the fixed flow rates. Finally, the chitosan microfiber was chosen as scaffold and the schwann cell and fibroblast cell with chitosan microfibers were used for cell culture to test effect in tissue engineering application.

AB - In this study, we successfully produced the chitosan microfibers using the proposed various angles of microfluidic chip, which was also been simulated. By controlling the core and sheath flow rates, we were able to generate laminar flow of different diameters from 15 μm to 40 μm. And the diameter of chitosan microfiber was measured from 20 μm to 50 μm. The microchannel of angle 30° could produce chitosan laminar flow of a smaller diameter than the angle 60° and angle 45° at the fixed flow rates. Finally, the chitosan microfiber was chosen as scaffold and the schwann cell and fibroblast cell with chitosan microfibers were used for cell culture to test effect in tissue engineering application.

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Yeh CS, Lin PW, Lin YC. Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 378-381. 5285485. (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2009.5285485

Chitosan microfiber fabrication using microfluidic chips of different sheath channel angles and its application on cell culture

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