Cholesterol biosensor based on nanoporous zinc oxide modified electrodes

Chia-Yu Lin; Kuo Chuan Ho

doi:10.1063/1.3156487

Cholesterol biosensor based on nanoporous zinc oxide modified electrodes

Chia-Yu Lin, Kuo Chuan Ho

Department of Chemical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

Nanostructured ZnO modified electrodes have been fabricated by co-electrodeposition with eosin Y onto Fdoped SnO2 (FTO) coated glass, and their application for cholesterol biosensor was studied. For cholesterol application, cholesterol oxidase (ChOx) was immobilized onto the ZnO/FTO electrode via physical adsorption. Cyclic voltammetric measurements showed that the ChOx/ZnO/FTO is sensitive to cholesterol and the optimal solution pH for the ChOx/ZnO/FTO electrode for detecting cholesterol was 6.7. Besides, the redox peak current densities are proportional to the square root of scan rate, or v1/2, indicating the electron-transfer process is diffusion limited. The sensitivity, linear detection range, and the limit of detection for the ChOx/ZnO/FTO electrode are 3.01 mA-cm2-M-1, 1.1~4.83 mM, and 20 uM, respectively.

Original language	English
Title of host publication	Olfaction and Electronic Nose - Proceedings of the 13th International Symposium on Olfaction and Electronic Nose, ISOEN
Pages	123-126
Number of pages	4
DOIs	https://doi.org/10.1063/1.3156487
Publication status	Published - 2009 Nov 27
Event	13th International Symposium on Olfaction and Electronic Nose, ISOEN - Brescia, Italy Duration: 2009 Apr 15 → 2009 Apr 17

Publication series

Name	AIP Conference Proceedings
Volume	1137
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Other

Other	13th International Symposium on Olfaction and Electronic Nose, ISOEN
Country/Territory	Italy
City	Brescia
Period	09-04-15 → 09-04-17

All Science Journal Classification (ASJC) codes

General Physics and Astronomy

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10.1063/1.3156487

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title = "Cholesterol biosensor based on nanoporous zinc oxide modified electrodes",

abstract = "Nanostructured ZnO modified electrodes have been fabricated by co-electrodeposition with eosin Y onto Fdoped SnO2 (FTO) coated glass, and their application for cholesterol biosensor was studied. For cholesterol application, cholesterol oxidase (ChOx) was immobilized onto the ZnO/FTO electrode via physical adsorption. Cyclic voltammetric measurements showed that the ChOx/ZnO/FTO is sensitive to cholesterol and the optimal solution pH for the ChOx/ZnO/FTO electrode for detecting cholesterol was 6.7. Besides, the redox peak current densities are proportional to the square root of scan rate, or v1/2, indicating the electron-transfer process is diffusion limited. The sensitivity, linear detection range, and the limit of detection for the ChOx/ZnO/FTO electrode are 3.01 mA-cm2-M-1, 1.1~4.83 mM, and 20 uM, respectively.",

author = "Chia-Yu Lin and Ho, {Kuo Chuan}",

year = "2009",

month = nov,

day = "27",

doi = "10.1063/1.3156487",

language = "English",

isbn = "9780735406742",

series = "AIP Conference Proceedings",

pages = "123--126",

booktitle = "Olfaction and Electronic Nose - Proceedings of the 13th International Symposium on Olfaction and Electronic Nose, ISOEN",

note = "13th International Symposium on Olfaction and Electronic Nose, ISOEN ; Conference date: 15-04-2009 Through 17-04-2009",

}

Lin, C-Y & Ho, KC 2009, Cholesterol biosensor based on nanoporous zinc oxide modified electrodes. in Olfaction and Electronic Nose - Proceedings of the 13th International Symposium on Olfaction and Electronic Nose, ISOEN. AIP Conference Proceedings, vol. 1137, pp. 123-126, 13th International Symposium on Olfaction and Electronic Nose, ISOEN, Brescia, Italy, 09-04-15. https://doi.org/10.1063/1.3156487

Cholesterol biosensor based on nanoporous zinc oxide modified electrodes. / Lin, Chia-Yu; Ho, Kuo Chuan.
Olfaction and Electronic Nose - Proceedings of the 13th International Symposium on Olfaction and Electronic Nose, ISOEN. 2009. p. 123-126 (AIP Conference Proceedings; Vol. 1137).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Cholesterol biosensor based on nanoporous zinc oxide modified electrodes

AU - Lin, Chia-Yu

AU - Ho, Kuo Chuan

PY - 2009/11/27

Y1 - 2009/11/27

N2 - Nanostructured ZnO modified electrodes have been fabricated by co-electrodeposition with eosin Y onto Fdoped SnO2 (FTO) coated glass, and their application for cholesterol biosensor was studied. For cholesterol application, cholesterol oxidase (ChOx) was immobilized onto the ZnO/FTO electrode via physical adsorption. Cyclic voltammetric measurements showed that the ChOx/ZnO/FTO is sensitive to cholesterol and the optimal solution pH for the ChOx/ZnO/FTO electrode for detecting cholesterol was 6.7. Besides, the redox peak current densities are proportional to the square root of scan rate, or v1/2, indicating the electron-transfer process is diffusion limited. The sensitivity, linear detection range, and the limit of detection for the ChOx/ZnO/FTO electrode are 3.01 mA-cm2-M-1, 1.1~4.83 mM, and 20 uM, respectively.

AB - Nanostructured ZnO modified electrodes have been fabricated by co-electrodeposition with eosin Y onto Fdoped SnO2 (FTO) coated glass, and their application for cholesterol biosensor was studied. For cholesterol application, cholesterol oxidase (ChOx) was immobilized onto the ZnO/FTO electrode via physical adsorption. Cyclic voltammetric measurements showed that the ChOx/ZnO/FTO is sensitive to cholesterol and the optimal solution pH for the ChOx/ZnO/FTO electrode for detecting cholesterol was 6.7. Besides, the redox peak current densities are proportional to the square root of scan rate, or v1/2, indicating the electron-transfer process is diffusion limited. The sensitivity, linear detection range, and the limit of detection for the ChOx/ZnO/FTO electrode are 3.01 mA-cm2-M-1, 1.1~4.83 mM, and 20 uM, respectively.

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Cholesterol biosensor based on nanoporous zinc oxide modified electrodes

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