Two lipid-like double-chained catanionic surfactants (decyltrimethylammonium-tetradecyl sulfate, DeTMA-TS, and dodecyltrimethylammonium-dodecyl sulfate, DTMA-DS) were prepared from single-chained cationic and anionic surfactants, and thereafter used as the material to generate the ethosome-like catanionic vesicles with the aid of cosolvent ethanol (20 v/v%) in an aqueous buffer solution by a simple semispontaneous process. The potential application of the ethosome-like catanionic vesicles as nano-carriers in dermal drug delivery was demonstrated by the encapsulation of vitamin E acetate (α-tocopherol acetate, α-TA). Effects of cholesterol addition on the encapsulation efficiency and vesicular membrane rigidity of the as-prepared ethosome-like catanionic vesicles were systematically studied. The experimental results revealed that DeTMA-TS and DTMADS systems exhibited opposite cholesterol effects on drug encapsulation efficiency. This has been explained by the opposite effects of cholesterol on the vesicular membrane rigidity of the two distinct systems. Condensation effect and the reverse one of cholesterol on the catanionic vesicular membrane rigidity at temperatures above and below, respectively, the gel to liquid crystalline phase transition temperature were discussed based on the results obtained by differential scanning calorimetry. It was shown that hydrophobic drug encapsulation efficiency and vesicular membrane rigidity of ethosome-like catanionic vesicles are positively correlated.
All Science Journal Classification (ASJC) codes
- Materials Science(all)