Cholinergic deafferentation of the rabbit cortex: A new animal model of Aβ deposition

Thomas G. Beach, Pamela E. Potter, Yu Min Kuo, Mark R. Emmerling, Robert A. Durham, Scott D. Webster, Douglas G. Walker, Lucia I. Sue, Sarah Scott, Kathryn J. Layne, Alex E. Roher

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


Brain deposition of the amyloid β-peptide (Aβ) is a critical step in the pathogenesis of Alzheimer's disease (AD) and human cerebral amyloid angiopathy (CAA). A small fraction of AD and CAA cases are caused by gene mutations leading to increased production and deposition of Aβ, but for the majority, there is no known direct genetic cause. We have hypothesized that Aβ deposition in these sporadic cases occurs as a result of cortical cholinergic deafferentation. Here we show that cortical cholinergic deafferentation, induced in rabbits by a selective immunotoxin, leads to Aβ deposition in cerebral blood vessels and perivascular neuropil. Biochemical measurements confirmed that lesioned animals had 2.5- and 8-fold elevations of cortical Aβ40 and Aβ42, respectively. Cholinergic deafferentation may be one factor that can contribute to Aβ deposition. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2000 Mar 31

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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