TY - JOUR
T1 - Chronic fluoxetine administration desensitizes the hyperglycemia but not the anorexia induced by serotonin in rats receiving fructose-enriched chow
AU - Hsiao, Sheng Huang
AU - Chung, Hsien Hui
AU - Tong, Yat Ching
AU - Cheng, Juei Tang
N1 - Funding Information:
We appreciate Miss M.J. Wang for her kind assistance. The present study was supported in part by a grant from the National Science Council (NSC 93-2320-B-006-010) of Taiwan, Republic of China.
PY - 2006/8/14
Y1 - 2006/8/14
N2 - The present study examined the effect of chronic fluoxetine administration on the feeding behavior of fructose-fed rats. Male fructose-fed rats were divided into two groups: (1) control fructose-fed rats (CFR), and (2) fructose-fed rats treated with oral fluoxetine 5 mg/kg/day for 30 days (FFR). The feeding behaviors and plasma glucose levels in response to either serotonin (5-HT, 5 mg/kg) or saline injection were studied. The results showed 5-HT increased CFR plasma glucose in a dose-dependent fashion while FFR demonstrated significantly lower responses to 5-HT stimulation. 5-HT significantly increased the feeding latency and decreased the amount of food intake in the CFR. Fluoxetine treatment did not affect the 5-HT effect on food intake amount but significantly reduced the 5-HT effect on feeding latency. Putting the animals in a new environment increased the 5-HT effect on feeding latency further; the effect was ameliorated in the FFR. In conclusion, 5-HT induced hyperglycemia, increased feeding latency and decreased food intake amount in fructose-fed rats. Chronic administration of fluoxetine counteracted the 5-HT effects on blood glucose level and feeding latency, but not on the amount of food intake.
AB - The present study examined the effect of chronic fluoxetine administration on the feeding behavior of fructose-fed rats. Male fructose-fed rats were divided into two groups: (1) control fructose-fed rats (CFR), and (2) fructose-fed rats treated with oral fluoxetine 5 mg/kg/day for 30 days (FFR). The feeding behaviors and plasma glucose levels in response to either serotonin (5-HT, 5 mg/kg) or saline injection were studied. The results showed 5-HT increased CFR plasma glucose in a dose-dependent fashion while FFR demonstrated significantly lower responses to 5-HT stimulation. 5-HT significantly increased the feeding latency and decreased the amount of food intake in the CFR. Fluoxetine treatment did not affect the 5-HT effect on food intake amount but significantly reduced the 5-HT effect on feeding latency. Putting the animals in a new environment increased the 5-HT effect on feeding latency further; the effect was ameliorated in the FFR. In conclusion, 5-HT induced hyperglycemia, increased feeding latency and decreased food intake amount in fructose-fed rats. Chronic administration of fluoxetine counteracted the 5-HT effects on blood glucose level and feeding latency, but not on the amount of food intake.
UR - http://www.scopus.com/inward/record.url?scp=33745906557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745906557&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2006.05.011
DO - 10.1016/j.neulet.2006.05.011
M3 - Article
C2 - 16782272
AN - SCOPUS:33745906557
SN - 0304-3940
VL - 404
SP - 6
EP - 8
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -