Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus

C. C. Hsu, S. J. Hwang, T. Y. Tai, T. Chen, M. C. Huang, S. J. Shin, C. P. Wen, Y. T. Shih, H. J. Yang, C. T. Chang, Chih-Jen Chang, C. H. Loh, M. T. Fuh, Y. S. Li, H. Y. Chang

Research output: Contribution to journalArticle

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Abstract

Aims: Cigarette smoking is a well-known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose-response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods: Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack-years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin-to-creatinine ratio was ≥ 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results: Compared with non-smokers, those who had smoked 15-30 or more than 30 pack-years were respectively 2.78 (95% CI 1.34-5.76, P < 0.01) and 3.20 (95% CI 1.74-5.86, P < 0.001) times more likely to develop proteinuria. The dose-response effect of tobacco exposure on the development of proteinuria is highly significant in all subjects (P = 0.001) and in subgroups with relatively short duration of diabetes mellitus (P < 0.001), good blood pressure control (P = 0.001) and those of young age (P = 0.007). Conclusions: The current study shows a clear dose-response effect of cigarette smoking on development of proteinuria in male Type 2 diabetic patients. These findings reinforce the urgent need to encourage diabetic patients to stop smoking regardless of age, duration of diabetes mellitus or status of blood pressure control.

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalDiabetic Medicine
Volume27
Issue number3
DOIs
Publication statusPublished - 2010 Jan 1

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Proteinuria
Type 2 Diabetes Mellitus
Smoking
Tobacco
Diabetes Mellitus
Blood Pressure
Diabetic Nephropathies
Taiwan
Albumins
Creatinine
Logistic Models
Urine
Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Hsu, C. C., Hwang, S. J., Tai, T. Y., Chen, T., Huang, M. C., Shin, S. J., ... Chang, H. Y. (2010). Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus. Diabetic Medicine, 27(3), 295-302. https://doi.org/10.1111/j.1464-5491.2010.02947.x
Hsu, C. C. ; Hwang, S. J. ; Tai, T. Y. ; Chen, T. ; Huang, M. C. ; Shin, S. J. ; Wen, C. P. ; Shih, Y. T. ; Yang, H. J. ; Chang, C. T. ; Chang, Chih-Jen ; Loh, C. H. ; Fuh, M. T. ; Li, Y. S. ; Chang, H. Y. / Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus. In: Diabetic Medicine. 2010 ; Vol. 27, No. 3. pp. 295-302.
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abstract = "Aims: Cigarette smoking is a well-known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose-response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods: Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack-years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin-to-creatinine ratio was ≥ 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results: Compared with non-smokers, those who had smoked 15-30 or more than 30 pack-years were respectively 2.78 (95{\%} CI 1.34-5.76, P < 0.01) and 3.20 (95{\%} CI 1.74-5.86, P < 0.001) times more likely to develop proteinuria. The dose-response effect of tobacco exposure on the development of proteinuria is highly significant in all subjects (P = 0.001) and in subgroups with relatively short duration of diabetes mellitus (P < 0.001), good blood pressure control (P = 0.001) and those of young age (P = 0.007). Conclusions: The current study shows a clear dose-response effect of cigarette smoking on development of proteinuria in male Type 2 diabetic patients. These findings reinforce the urgent need to encourage diabetic patients to stop smoking regardless of age, duration of diabetes mellitus or status of blood pressure control.",
author = "Hsu, {C. C.} and Hwang, {S. J.} and Tai, {T. Y.} and T. Chen and Huang, {M. C.} and Shin, {S. J.} and Wen, {C. P.} and Shih, {Y. T.} and Yang, {H. J.} and Chang, {C. T.} and Chih-Jen Chang and Loh, {C. H.} and Fuh, {M. T.} and Li, {Y. S.} and Chang, {H. Y.}",
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Hsu, CC, Hwang, SJ, Tai, TY, Chen, T, Huang, MC, Shin, SJ, Wen, CP, Shih, YT, Yang, HJ, Chang, CT, Chang, C-J, Loh, CH, Fuh, MT, Li, YS & Chang, HY 2010, 'Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus', Diabetic Medicine, vol. 27, no. 3, pp. 295-302. https://doi.org/10.1111/j.1464-5491.2010.02947.x

Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus. / Hsu, C. C.; Hwang, S. J.; Tai, T. Y.; Chen, T.; Huang, M. C.; Shin, S. J.; Wen, C. P.; Shih, Y. T.; Yang, H. J.; Chang, C. T.; Chang, Chih-Jen; Loh, C. H.; Fuh, M. T.; Li, Y. S.; Chang, H. Y.

In: Diabetic Medicine, Vol. 27, No. 3, 01.01.2010, p. 295-302.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus

AU - Hsu, C. C.

AU - Hwang, S. J.

AU - Tai, T. Y.

AU - Chen, T.

AU - Huang, M. C.

AU - Shin, S. J.

AU - Wen, C. P.

AU - Shih, Y. T.

AU - Yang, H. J.

AU - Chang, C. T.

AU - Chang, Chih-Jen

AU - Loh, C. H.

AU - Fuh, M. T.

AU - Li, Y. S.

AU - Chang, H. Y.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Aims: Cigarette smoking is a well-known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose-response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods: Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack-years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin-to-creatinine ratio was ≥ 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results: Compared with non-smokers, those who had smoked 15-30 or more than 30 pack-years were respectively 2.78 (95% CI 1.34-5.76, P < 0.01) and 3.20 (95% CI 1.74-5.86, P < 0.001) times more likely to develop proteinuria. The dose-response effect of tobacco exposure on the development of proteinuria is highly significant in all subjects (P = 0.001) and in subgroups with relatively short duration of diabetes mellitus (P < 0.001), good blood pressure control (P = 0.001) and those of young age (P = 0.007). Conclusions: The current study shows a clear dose-response effect of cigarette smoking on development of proteinuria in male Type 2 diabetic patients. These findings reinforce the urgent need to encourage diabetic patients to stop smoking regardless of age, duration of diabetes mellitus or status of blood pressure control.

AB - Aims: Cigarette smoking is a well-known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose-response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods: Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack-years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin-to-creatinine ratio was ≥ 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results: Compared with non-smokers, those who had smoked 15-30 or more than 30 pack-years were respectively 2.78 (95% CI 1.34-5.76, P < 0.01) and 3.20 (95% CI 1.74-5.86, P < 0.001) times more likely to develop proteinuria. The dose-response effect of tobacco exposure on the development of proteinuria is highly significant in all subjects (P = 0.001) and in subgroups with relatively short duration of diabetes mellitus (P < 0.001), good blood pressure control (P = 0.001) and those of young age (P = 0.007). Conclusions: The current study shows a clear dose-response effect of cigarette smoking on development of proteinuria in male Type 2 diabetic patients. These findings reinforce the urgent need to encourage diabetic patients to stop smoking regardless of age, duration of diabetes mellitus or status of blood pressure control.

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