Circulating cells contribute to cardiomyocyte regeneration after injury

Jasmine M.F. Wu, Ying Chang Hsueh, Hui Ju Ch'ang, Chwan Yau Luo, Li Wha Wu, Hiromitsu Nakauchi, Patrick C.H. Hsieh

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Rationale: The contribution of bone marrow-borne hematopoietic cells to the ischemic myocardium has been documented. However, a pivotal study reported no evidence of myocardial regeneration from hematopoieticderived cells. The study did not take into account the possible effect of early injury-induced signaling as the test mice were parabiotically paired to partners immediately after surgery-induced myocardial injury when cross-circulation has not yet developed. Objective: To re-evaluate the role of circulating cells in the injured myocardium. Methods and Results: By combining pulse-chase labeling and parabiosis model, we show that circulating cells derived from the parabiont expressed cardiac-specific markers in the injured myocardium. Genetic fate mapping also revealed that circulating hematopoietic cells acquired cardiac cell fate by means of cell fusion and transdifferentiation. Conclusions: These results suggest that circulating cells participate in cardiomyocyte regeneration in a mouse model of parabiosis when the circulatory system is fully developed before surgery-induced heart injury.

Original languageEnglish
Pages (from-to)633-641
Number of pages9
JournalCirculation Research
Volume116
Issue number4
DOIs
Publication statusPublished - 2015 Feb 13

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

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