Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan

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Abstract

Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throat swab or nasopharyngeal aspirates at a tertiary care university hospital, between January 2012 and December 2014. HPIV4 was not checked and analyzed, due to not include in the commercial kit. The demographic, epidemiological, clinical presentations, diagnosis, treatment, outcomes, and laboratory data were analyzed. Results: Totally 398 cases were enrolled, including 39 (9.8%) of HPIV1, 67 (16.8%) of HPIV2, and 292 (73.4%) of HPIV3. The mean age of HPIV-infected children was 2.9 year-old, and 50.5% were among one to three year-old. A total of 56.8% HPIV3-infected children were among one to three years old, however, no HPIV2-infected children was younger than one year-old. The HPIV1-infected patients were more common to develop wheezing and diagnose as acute bronchiolitis. HPIV2-infected children were more likely to have hoarseness (23.9%), and were associated with croup (25.4%). HPIV3 was isolated from two fatal cases, with neurological underlying diseases. Conclusion: The impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management.

Original languageEnglish
Pages (from-to)749-755
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Volume51
Issue number6
DOIs
Publication statusPublished - 2018 Dec 1

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Paramyxoviridae Infections
Taiwan
Croup
Viruses
Hoarseness
Bronchiolitis
Hospitalized Child
Respiratory Sounds
Tertiary Healthcare
Pharynx
Respiratory Tract Infections
Respiratory System
Hospitalization
Retrospective Studies
Demography
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{567dd1cf2bd84127943fe7ae2517cd7b,
title = "Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan",
abstract = "Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throat swab or nasopharyngeal aspirates at a tertiary care university hospital, between January 2012 and December 2014. HPIV4 was not checked and analyzed, due to not include in the commercial kit. The demographic, epidemiological, clinical presentations, diagnosis, treatment, outcomes, and laboratory data were analyzed. Results: Totally 398 cases were enrolled, including 39 (9.8{\%}) of HPIV1, 67 (16.8{\%}) of HPIV2, and 292 (73.4{\%}) of HPIV3. The mean age of HPIV-infected children was 2.9 year-old, and 50.5{\%} were among one to three year-old. A total of 56.8{\%} HPIV3-infected children were among one to three years old, however, no HPIV2-infected children was younger than one year-old. The HPIV1-infected patients were more common to develop wheezing and diagnose as acute bronchiolitis. HPIV2-infected children were more likely to have hoarseness (23.9{\%}), and were associated with croup (25.4{\%}). HPIV3 was isolated from two fatal cases, with neurological underlying diseases. Conclusion: The impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management.",
author = "Wu, {Kai Wen} and Shih-Min Wang and Ching-Fen Shen and Tzong-Shiann Ho and Jen-Ren Wang and Ching-Chuan Liu",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.jmii.2016.08.017",
language = "English",
volume = "51",
pages = "749--755",
journal = "Journal of Microbiology, Immunology and Infection",
issn = "1684-1182",
publisher = "Elsevier Taiwan LLC",
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}

TY - JOUR

T1 - Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan

AU - Wu, Kai Wen

AU - Wang, Shih-Min

AU - Shen, Ching-Fen

AU - Ho, Tzong-Shiann

AU - Wang, Jen-Ren

AU - Liu, Ching-Chuan

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throat swab or nasopharyngeal aspirates at a tertiary care university hospital, between January 2012 and December 2014. HPIV4 was not checked and analyzed, due to not include in the commercial kit. The demographic, epidemiological, clinical presentations, diagnosis, treatment, outcomes, and laboratory data were analyzed. Results: Totally 398 cases were enrolled, including 39 (9.8%) of HPIV1, 67 (16.8%) of HPIV2, and 292 (73.4%) of HPIV3. The mean age of HPIV-infected children was 2.9 year-old, and 50.5% were among one to three year-old. A total of 56.8% HPIV3-infected children were among one to three years old, however, no HPIV2-infected children was younger than one year-old. The HPIV1-infected patients were more common to develop wheezing and diagnose as acute bronchiolitis. HPIV2-infected children were more likely to have hoarseness (23.9%), and were associated with croup (25.4%). HPIV3 was isolated from two fatal cases, with neurological underlying diseases. Conclusion: The impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management.

AB - Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throat swab or nasopharyngeal aspirates at a tertiary care university hospital, between January 2012 and December 2014. HPIV4 was not checked and analyzed, due to not include in the commercial kit. The demographic, epidemiological, clinical presentations, diagnosis, treatment, outcomes, and laboratory data were analyzed. Results: Totally 398 cases were enrolled, including 39 (9.8%) of HPIV1, 67 (16.8%) of HPIV2, and 292 (73.4%) of HPIV3. The mean age of HPIV-infected children was 2.9 year-old, and 50.5% were among one to three year-old. A total of 56.8% HPIV3-infected children were among one to three years old, however, no HPIV2-infected children was younger than one year-old. The HPIV1-infected patients were more common to develop wheezing and diagnose as acute bronchiolitis. HPIV2-infected children were more likely to have hoarseness (23.9%), and were associated with croup (25.4%). HPIV3 was isolated from two fatal cases, with neurological underlying diseases. Conclusion: The impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management.

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DO - 10.1016/j.jmii.2016.08.017

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JO - Journal of Microbiology, Immunology and Infection

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SN - 1684-1182

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