Clinical and histological effects of aortic infusion of methotrexate for penile squamous cell carcinoma

M. C. Sheen, H. M. Sheu, C. Y. Chai, C. H. Huang, J. H. Chuang, T. M. Lin, Y. W. Wang

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4 Citations (Scopus)

Abstract

From 1985 to 1992, 9 patients with advanced squamous cell carcinoma of the penis were treated by intra-aortic infusion chemotherapy. The age ranged from 27 to 76 years old. The catheter (Jet Port Plus Allround) was inserted retrogradely through the lateral circumflex artery into the abdominal aorta. The catheter tip was placed at about the level of the third lumbar vertebra. Treatment consisting of continuous intra-aortic infusion with methotrexate 50 mg/24h using a portable pump and simultaneous intramuscular injection of citrovorum factor 6 mg/th was given for a mean of 9 days. Five patients achieved complete remission. They are living disease-free 92, 86, 56, 39, 22 months after initial therapy at the time of follow-up (Aug. 1993). For young patients post-infusion evaluations including semen analysis, rigiscan for erectile function and duplex sonography for penile blood flow all revealed no abnormal changes. This therapeutic modality is a simple and effective method for advanced penile carcinoma with the unique advantages of anatomical and functional preservation not only of the external genitals but also the reproductive organs.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalRegional Cancer Treatment
Volume7
Issue number1
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology

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    Sheen, M. C., Sheu, H. M., Chai, C. Y., Huang, C. H., Chuang, J. H., Lin, T. M., & Wang, Y. W. (1994). Clinical and histological effects of aortic infusion of methotrexate for penile squamous cell carcinoma. Regional Cancer Treatment, 7(1), 27-32.