Clinical and microbiological characteristics of recurrent group B streptococcal infection among non-pregnant adults

Ying Hsiang Wang, Hung Ming Chen, Yun Hsuan Yang, Tsung Han Yang, Ching-Hao Teng, Chyi Liang Chen, Chishih Chu, Cheng Hsun Chiu

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Abstract

Objective: This study aimed to investigate the clinical and microbiological features of recurrent group B streptococcal (GBS) diseases among non-pregnant adults. Methods: All hospitalized non-pregnant adults who had culture-proven GBS infections between January 2008 and December 2010 were enrolled in this retrospective study. Bacterial isolates were examined for their serotypes, genotypes, and antimicrobial resistance. Results: The recurrence rate of GBS infection in Taiwan was found to be 9.3%. Of the 70 recurrent episodes in 32 patients, infections of the urinary tract (U) were diagnosed clinically in 55.7%, infections of the soft tissue (S) in 31.4%, and infections of the bloodstream (B) in 12.9%. The initial/recurrent episodes in 25 patients were mainly U/U (40.6%), followed by S/S (18.8%) and B/B (6.2%). The serotypes/serogroups identified were serotypes V (34.3%), Ib (22.9%), VI (17.1%), III (12.9%), IV (7.1%), and Ia (5.7%). Recurrent strains showed less resistance to erythromycin or clindamycin than non-recurrent strains. Six distinct genotypes were identified in 12 serotype VI isolates derived from seven patients; five of these isolate pairs had identical genotypes. Conclusions: Recurrent GBS diseases were found to occur considerably more often than previously thought, mainly in adults with a high comorbid index. Relapse, not new acquisition, was found to be more common.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume26
DOIs
Publication statusPublished - 2014 Jan 1

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Streptococcal Infections
Genotype
Recurrence
Soft Tissue Infections
Clindamycin
Erythromycin
Taiwan
Urinary Tract Infections
Retrospective Studies
Serogroup
Infection

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Wang, Ying Hsiang ; Chen, Hung Ming ; Yang, Yun Hsuan ; Yang, Tsung Han ; Teng, Ching-Hao ; Chen, Chyi Liang ; Chu, Chishih ; Chiu, Cheng Hsun. / Clinical and microbiological characteristics of recurrent group B streptococcal infection among non-pregnant adults. In: International Journal of Infectious Diseases. 2014 ; Vol. 26.
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abstract = "Objective: This study aimed to investigate the clinical and microbiological features of recurrent group B streptococcal (GBS) diseases among non-pregnant adults. Methods: All hospitalized non-pregnant adults who had culture-proven GBS infections between January 2008 and December 2010 were enrolled in this retrospective study. Bacterial isolates were examined for their serotypes, genotypes, and antimicrobial resistance. Results: The recurrence rate of GBS infection in Taiwan was found to be 9.3{\%}. Of the 70 recurrent episodes in 32 patients, infections of the urinary tract (U) were diagnosed clinically in 55.7{\%}, infections of the soft tissue (S) in 31.4{\%}, and infections of the bloodstream (B) in 12.9{\%}. The initial/recurrent episodes in 25 patients were mainly U/U (40.6{\%}), followed by S/S (18.8{\%}) and B/B (6.2{\%}). The serotypes/serogroups identified were serotypes V (34.3{\%}), Ib (22.9{\%}), VI (17.1{\%}), III (12.9{\%}), IV (7.1{\%}), and Ia (5.7{\%}). Recurrent strains showed less resistance to erythromycin or clindamycin than non-recurrent strains. Six distinct genotypes were identified in 12 serotype VI isolates derived from seven patients; five of these isolate pairs had identical genotypes. Conclusions: Recurrent GBS diseases were found to occur considerably more often than previously thought, mainly in adults with a high comorbid index. Relapse, not new acquisition, was found to be more common.",
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Clinical and microbiological characteristics of recurrent group B streptococcal infection among non-pregnant adults. / Wang, Ying Hsiang; Chen, Hung Ming; Yang, Yun Hsuan; Yang, Tsung Han; Teng, Ching-Hao; Chen, Chyi Liang; Chu, Chishih; Chiu, Cheng Hsun.

In: International Journal of Infectious Diseases, Vol. 26, 01.01.2014.

Research output: Contribution to journalArticle

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AU - Wang, Ying Hsiang

AU - Chen, Hung Ming

AU - Yang, Yun Hsuan

AU - Yang, Tsung Han

AU - Teng, Ching-Hao

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AU - Chu, Chishih

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N2 - Objective: This study aimed to investigate the clinical and microbiological features of recurrent group B streptococcal (GBS) diseases among non-pregnant adults. Methods: All hospitalized non-pregnant adults who had culture-proven GBS infections between January 2008 and December 2010 were enrolled in this retrospective study. Bacterial isolates were examined for their serotypes, genotypes, and antimicrobial resistance. Results: The recurrence rate of GBS infection in Taiwan was found to be 9.3%. Of the 70 recurrent episodes in 32 patients, infections of the urinary tract (U) were diagnosed clinically in 55.7%, infections of the soft tissue (S) in 31.4%, and infections of the bloodstream (B) in 12.9%. The initial/recurrent episodes in 25 patients were mainly U/U (40.6%), followed by S/S (18.8%) and B/B (6.2%). The serotypes/serogroups identified were serotypes V (34.3%), Ib (22.9%), VI (17.1%), III (12.9%), IV (7.1%), and Ia (5.7%). Recurrent strains showed less resistance to erythromycin or clindamycin than non-recurrent strains. Six distinct genotypes were identified in 12 serotype VI isolates derived from seven patients; five of these isolate pairs had identical genotypes. Conclusions: Recurrent GBS diseases were found to occur considerably more often than previously thought, mainly in adults with a high comorbid index. Relapse, not new acquisition, was found to be more common.

AB - Objective: This study aimed to investigate the clinical and microbiological features of recurrent group B streptococcal (GBS) diseases among non-pregnant adults. Methods: All hospitalized non-pregnant adults who had culture-proven GBS infections between January 2008 and December 2010 were enrolled in this retrospective study. Bacterial isolates were examined for their serotypes, genotypes, and antimicrobial resistance. Results: The recurrence rate of GBS infection in Taiwan was found to be 9.3%. Of the 70 recurrent episodes in 32 patients, infections of the urinary tract (U) were diagnosed clinically in 55.7%, infections of the soft tissue (S) in 31.4%, and infections of the bloodstream (B) in 12.9%. The initial/recurrent episodes in 25 patients were mainly U/U (40.6%), followed by S/S (18.8%) and B/B (6.2%). The serotypes/serogroups identified were serotypes V (34.3%), Ib (22.9%), VI (17.1%), III (12.9%), IV (7.1%), and Ia (5.7%). Recurrent strains showed less resistance to erythromycin or clindamycin than non-recurrent strains. Six distinct genotypes were identified in 12 serotype VI isolates derived from seven patients; five of these isolate pairs had identical genotypes. Conclusions: Recurrent GBS diseases were found to occur considerably more often than previously thought, mainly in adults with a high comorbid index. Relapse, not new acquisition, was found to be more common.

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