Clinical experience of 13 cases with severe pulmonary hemorrhage in systemic lupus erythematosus with active nephritis

Ming-Fei Liu, Jiann Hsiung Lee, Tien Hsinng Weng, Yu-Yun Lee

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Abstract

Pulmonary hemorrhage is a rare, but serious manifestation of systemic lupus eythematosus (SLE). Herein, we report 13 cases of severe pulmonary hemorrhage in SLE. Hemoptysis was present in 11 patients. All thirteen patients had active nephritis and were in the stage of nephrotic syndrome. A majority of the patients had neuropsychiatric manifestations and coagulopathy including thrombocytopenia or lupus anticoagulant. All episodes of pulmonary hemorrhage occurred after large dose of corticosteroid had been administered in treating nephritis. Recurrent pulmonary hemorrhage was noted in four patients. Ten (77%) of the 13 patients finally died. Respiratory failure was the main cause of death. Our observation suggests that active nephritis with hypoalbuminemia is a major risk factor for severe pulmonary hemorrhage in SLE patients and that high dose corticosteroid use can not prevent the occurrence of severe pulmonary hemorrhage in SLE.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalScandinavian Journal of Rheumatology
Volume27
Issue number4
DOIs
Publication statusPublished - 1998 Sep 19

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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