Clinical features and outcome of patients with apical hypertrophic cardiomyopathy in Taiwan

Cheng Han Lee, Ping Yen Liu, Li Jen Lin, Jyh Hong Chen, Liang Miin Tsai

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Objectives: The aim of this study was to analyze clinical characteristics and the outcome of patients with apical hypertrophic cardiomyopathy (ApHCM) followed in a Taiwan tertiary referral medical center. Background: ApHCM is regarded as a subgroup of nonobstructive HCM that occurs largely in Japanese patients. The clinical features, gender differences and prognosis of the disease in Taiwan are poorly understood. Methods: A retrospective cohort study with 40 patients was performed. Diagnosis was based on the demonstration of left ventricular hypertrophy by echocardiography. Clinical features, cardiovascular morbidity and mortality were analyzed. Multiple logistic regression was used to adjust for potential confounding factors. Results: Among 40 patients, males predominated with a percentage of 75%. The female patients obviously had later onset of presentation (mean age ± SD, 62.2 ± 5.7 vs. 54.1 ± 11.4 years; p = 0.038). During a mean follow-up of 72.2 ± 60.1 months, there was no mortality. However, 13 patients (32.5%) had one or more major cardiovascular morbidities, the most frequent being syncope or near syncope (15%) and ischemic stroke-associated atrial fibrillation (10%). In a multivariate analysis, left atrial enlargement (odds ratio 5.85, 95% CI 1.15-29.40; p = 0.034) was the only predictor of cardiovascular morbidity. Conclusions: Patients with ApHCM in Taiwan have a benign clinical course without association with sudden death and cardiovascular mortality. Left atrial enlargement was the only identified predictor of cardiovascular morbidity

Original languageEnglish
Pages (from-to)29-35
Number of pages7
Issue number1
Publication statusPublished - 2006 Jun 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)


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