Clinical features of pandrug-resistant Acinetobacter baumannii bacteremia at a University Hospital in Taiwan

Lu Cheng Kuo, Chong Jen Yu, Li Na Lee, Jiun-Ling Wang, Hao Chien Wang, Po Ren Hsueh, Pan Chyr Yang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background and Purpose: The number of infections caused by Acinetobacter baumanni has increased in recent years and the emergence of pandrug-resistant A. baumannii (PDRAB) has been observed in Taiwan. The aim of this study was to evaluate the clinical features and outcomes of patients with bacteremia due to PDRAB. Methods: From January 1999 to April 2003, 30 patients with PDRAB bacteremia were treated. We analyzed the clinical characteristics of these patients, including gender, underlying disease, clinical manifestations, antibiotic treatment, and outcome. Results: Bacteremia develope an average of 33 days after hospitalization and was hospital acquired in all cases. The source of bacteremia was identified in 19 patients (63.3%) and was most commonly from the respiratory tract. The overall mortality was 60% (18 patients). Among these, the cause of death was directly related to PDRAB bacteremia in 12. Underlying heart disease, shock, resuscitation, acute respiratory distress syndrome, mechinical ventilation, and multiple organ dysfunctin score (MODS) were significant predictors of mortality after the development of PDRAB bacteremia. No specific antimicrobial therapy appeared to be effective. Conclusion: Clinical outcomes of patients with PDRAB bacteremia were related to the medical conditions of the patients at the times of development of bacteremia and could be predicted by the MODS. The only way to limit the spread is through stricy preventive measures for nosocomial infection and antibiotic control.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalJournal of the Formosan Medical Association
Volume102
Issue number9
Publication statusPublished - 2003 Sep 1

Fingerprint

Acinetobacter baumannii
Bacteremia
Taiwan
Acinetobacter Infections
Anti-Bacterial Agents
Mortality
Adult Respiratory Distress Syndrome
Infection Control
Cross Infection
Resuscitation
Respiratory System
Ventilation
Cause of Death
Heart Diseases
Shock
Hospitalization

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kuo, Lu Cheng ; Yu, Chong Jen ; Lee, Li Na ; Wang, Jiun-Ling ; Wang, Hao Chien ; Hsueh, Po Ren ; Yang, Pan Chyr. / Clinical features of pandrug-resistant Acinetobacter baumannii bacteremia at a University Hospital in Taiwan. In: Journal of the Formosan Medical Association. 2003 ; Vol. 102, No. 9. pp. 601-606.
@article{6809210dbc57442888f43b969e697d78,
title = "Clinical features of pandrug-resistant Acinetobacter baumannii bacteremia at a University Hospital in Taiwan",
abstract = "Background and Purpose: The number of infections caused by Acinetobacter baumanni has increased in recent years and the emergence of pandrug-resistant A. baumannii (PDRAB) has been observed in Taiwan. The aim of this study was to evaluate the clinical features and outcomes of patients with bacteremia due to PDRAB. Methods: From January 1999 to April 2003, 30 patients with PDRAB bacteremia were treated. We analyzed the clinical characteristics of these patients, including gender, underlying disease, clinical manifestations, antibiotic treatment, and outcome. Results: Bacteremia develope an average of 33 days after hospitalization and was hospital acquired in all cases. The source of bacteremia was identified in 19 patients (63.3{\%}) and was most commonly from the respiratory tract. The overall mortality was 60{\%} (18 patients). Among these, the cause of death was directly related to PDRAB bacteremia in 12. Underlying heart disease, shock, resuscitation, acute respiratory distress syndrome, mechinical ventilation, and multiple organ dysfunctin score (MODS) were significant predictors of mortality after the development of PDRAB bacteremia. No specific antimicrobial therapy appeared to be effective. Conclusion: Clinical outcomes of patients with PDRAB bacteremia were related to the medical conditions of the patients at the times of development of bacteremia and could be predicted by the MODS. The only way to limit the spread is through stricy preventive measures for nosocomial infection and antibiotic control.",
author = "Kuo, {Lu Cheng} and Yu, {Chong Jen} and Lee, {Li Na} and Jiun-Ling Wang and Wang, {Hao Chien} and Hsueh, {Po Ren} and Yang, {Pan Chyr}",
year = "2003",
month = "9",
day = "1",
language = "English",
volume = "102",
pages = "601--606",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Excerpta Medica Asia Ltd.",
number = "9",

}

Clinical features of pandrug-resistant Acinetobacter baumannii bacteremia at a University Hospital in Taiwan. / Kuo, Lu Cheng; Yu, Chong Jen; Lee, Li Na; Wang, Jiun-Ling; Wang, Hao Chien; Hsueh, Po Ren; Yang, Pan Chyr.

In: Journal of the Formosan Medical Association, Vol. 102, No. 9, 01.09.2003, p. 601-606.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical features of pandrug-resistant Acinetobacter baumannii bacteremia at a University Hospital in Taiwan

AU - Kuo, Lu Cheng

AU - Yu, Chong Jen

AU - Lee, Li Na

AU - Wang, Jiun-Ling

AU - Wang, Hao Chien

AU - Hsueh, Po Ren

AU - Yang, Pan Chyr

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background and Purpose: The number of infections caused by Acinetobacter baumanni has increased in recent years and the emergence of pandrug-resistant A. baumannii (PDRAB) has been observed in Taiwan. The aim of this study was to evaluate the clinical features and outcomes of patients with bacteremia due to PDRAB. Methods: From January 1999 to April 2003, 30 patients with PDRAB bacteremia were treated. We analyzed the clinical characteristics of these patients, including gender, underlying disease, clinical manifestations, antibiotic treatment, and outcome. Results: Bacteremia develope an average of 33 days after hospitalization and was hospital acquired in all cases. The source of bacteremia was identified in 19 patients (63.3%) and was most commonly from the respiratory tract. The overall mortality was 60% (18 patients). Among these, the cause of death was directly related to PDRAB bacteremia in 12. Underlying heart disease, shock, resuscitation, acute respiratory distress syndrome, mechinical ventilation, and multiple organ dysfunctin score (MODS) were significant predictors of mortality after the development of PDRAB bacteremia. No specific antimicrobial therapy appeared to be effective. Conclusion: Clinical outcomes of patients with PDRAB bacteremia were related to the medical conditions of the patients at the times of development of bacteremia and could be predicted by the MODS. The only way to limit the spread is through stricy preventive measures for nosocomial infection and antibiotic control.

AB - Background and Purpose: The number of infections caused by Acinetobacter baumanni has increased in recent years and the emergence of pandrug-resistant A. baumannii (PDRAB) has been observed in Taiwan. The aim of this study was to evaluate the clinical features and outcomes of patients with bacteremia due to PDRAB. Methods: From January 1999 to April 2003, 30 patients with PDRAB bacteremia were treated. We analyzed the clinical characteristics of these patients, including gender, underlying disease, clinical manifestations, antibiotic treatment, and outcome. Results: Bacteremia develope an average of 33 days after hospitalization and was hospital acquired in all cases. The source of bacteremia was identified in 19 patients (63.3%) and was most commonly from the respiratory tract. The overall mortality was 60% (18 patients). Among these, the cause of death was directly related to PDRAB bacteremia in 12. Underlying heart disease, shock, resuscitation, acute respiratory distress syndrome, mechinical ventilation, and multiple organ dysfunctin score (MODS) were significant predictors of mortality after the development of PDRAB bacteremia. No specific antimicrobial therapy appeared to be effective. Conclusion: Clinical outcomes of patients with PDRAB bacteremia were related to the medical conditions of the patients at the times of development of bacteremia and could be predicted by the MODS. The only way to limit the spread is through stricy preventive measures for nosocomial infection and antibiotic control.

UR - http://www.scopus.com/inward/record.url?scp=0345865147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345865147&partnerID=8YFLogxK

M3 - Article

VL - 102

SP - 601

EP - 606

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 9

ER -