Clinical implications and factors related to left atrial spontaneous echo contrast in chronic nonvalvular atrial fibrillation

Juey Jen Hwang, Feng Nien Ko, Yi-Heng Li, Huei Ming Ma, Gong Jhe Wu, Hang Chang, Shih Ming Wang, Jen Tsong Schie, Yung Zu Tseng, Peiliang Kuan, Che Ming Teng, Wen Pin Lien

Research output: Contribution to journalArticle

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Abstract

The mechanisms leading to formation of spontaneous echo contrast (SEC), a smoke-like echo on echocardiography, are still controversial. To further explore the clinical implications and factors related to SEC formation, the correlation among echocardiographic variables, hematologic parameters or platelet aggregability, and the occurrence of SEC was studied in 119 patients with chronic nonvalvular atrial fibrillation. There were 75 men and 44 women with a mean age of 65 ± 10 years (range 38-88). Left atrial SEC was detected in 39 patients (33%) by transesophageal echocardiography. Patients with history of systemic embolism were more frequently found to have left atrial SEC and left atrial thrombus by univariate analysis. Multivariate analysis showed that left atrial SEC (p < 0.001) was the only independent predictor of history of systemic embolism. Age, sex, left atrial or left ventricular dimension, left ventricular ejection fraction, antiplatelet or anticoagulant therapy and the percentage of lone atrial fibrillation were not significantly different between patients with and without left atrial SEC. Among the hematologic parameters, higher hematocrit was found in patients with left atrial SEC, while white blood cell and platelet counts were comparable in both groups. Platelet aggregability with different concentrations of inducers, adenosine diphosphate and collagen, was evaluated by the turbidimetric method in 15 patients with left atrial SEC and in 42 patients without left atrial SEC who were not receiving antiplatelet or anticoagulant therapy. No significant difference was found in platelet aggregability using four inducer concentrations between two groups of patients. It is therefore concluded that SEC formation is related to the hematocrit level in patients with nonvalvular atrial fibrillation, and the results also support the hypothesis that left atrial SEC comes from erythrocyte aggregation.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalCardiology (Switzerland)
Volume85
Issue number2
DOIs
Publication statusPublished - 1994 Jan 1

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Atrial Fibrillation
Blood Platelets
Embolism
Hematocrit
Anticoagulants
Erythrocyte Aggregation
Transesophageal Echocardiography
Platelet Count
Leukocyte Count
Smoke
Stroke Volume
Adenosine Diphosphate
Echocardiography
Thrombosis
Collagen
Multivariate Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Hwang, Juey Jen ; Ko, Feng Nien ; Li, Yi-Heng ; Ma, Huei Ming ; Wu, Gong Jhe ; Chang, Hang ; Wang, Shih Ming ; Schie, Jen Tsong ; Tseng, Yung Zu ; Kuan, Peiliang ; Teng, Che Ming ; Lien, Wen Pin. / Clinical implications and factors related to left atrial spontaneous echo contrast in chronic nonvalvular atrial fibrillation. In: Cardiology (Switzerland). 1994 ; Vol. 85, No. 2. pp. 69-75.
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title = "Clinical implications and factors related to left atrial spontaneous echo contrast in chronic nonvalvular atrial fibrillation",
abstract = "The mechanisms leading to formation of spontaneous echo contrast (SEC), a smoke-like echo on echocardiography, are still controversial. To further explore the clinical implications and factors related to SEC formation, the correlation among echocardiographic variables, hematologic parameters or platelet aggregability, and the occurrence of SEC was studied in 119 patients with chronic nonvalvular atrial fibrillation. There were 75 men and 44 women with a mean age of 65 ± 10 years (range 38-88). Left atrial SEC was detected in 39 patients (33{\%}) by transesophageal echocardiography. Patients with history of systemic embolism were more frequently found to have left atrial SEC and left atrial thrombus by univariate analysis. Multivariate analysis showed that left atrial SEC (p < 0.001) was the only independent predictor of history of systemic embolism. Age, sex, left atrial or left ventricular dimension, left ventricular ejection fraction, antiplatelet or anticoagulant therapy and the percentage of lone atrial fibrillation were not significantly different between patients with and without left atrial SEC. Among the hematologic parameters, higher hematocrit was found in patients with left atrial SEC, while white blood cell and platelet counts were comparable in both groups. Platelet aggregability with different concentrations of inducers, adenosine diphosphate and collagen, was evaluated by the turbidimetric method in 15 patients with left atrial SEC and in 42 patients without left atrial SEC who were not receiving antiplatelet or anticoagulant therapy. No significant difference was found in platelet aggregability using four inducer concentrations between two groups of patients. It is therefore concluded that SEC formation is related to the hematocrit level in patients with nonvalvular atrial fibrillation, and the results also support the hypothesis that left atrial SEC comes from erythrocyte aggregation.",
author = "Hwang, {Juey Jen} and Ko, {Feng Nien} and Yi-Heng Li and Ma, {Huei Ming} and Wu, {Gong Jhe} and Hang Chang and Wang, {Shih Ming} and Schie, {Jen Tsong} and Tseng, {Yung Zu} and Peiliang Kuan and Teng, {Che Ming} and Lien, {Wen Pin}",
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Hwang, JJ, Ko, FN, Li, Y-H, Ma, HM, Wu, GJ, Chang, H, Wang, SM, Schie, JT, Tseng, YZ, Kuan, P, Teng, CM & Lien, WP 1994, 'Clinical implications and factors related to left atrial spontaneous echo contrast in chronic nonvalvular atrial fibrillation', Cardiology (Switzerland), vol. 85, no. 2, pp. 69-75. https://doi.org/10.1159/000176648

Clinical implications and factors related to left atrial spontaneous echo contrast in chronic nonvalvular atrial fibrillation. / Hwang, Juey Jen; Ko, Feng Nien; Li, Yi-Heng; Ma, Huei Ming; Wu, Gong Jhe; Chang, Hang; Wang, Shih Ming; Schie, Jen Tsong; Tseng, Yung Zu; Kuan, Peiliang; Teng, Che Ming; Lien, Wen Pin.

In: Cardiology (Switzerland), Vol. 85, No. 2, 01.01.1994, p. 69-75.

Research output: Contribution to journalArticle

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T1 - Clinical implications and factors related to left atrial spontaneous echo contrast in chronic nonvalvular atrial fibrillation

AU - Hwang, Juey Jen

AU - Ko, Feng Nien

AU - Li, Yi-Heng

AU - Ma, Huei Ming

AU - Wu, Gong Jhe

AU - Chang, Hang

AU - Wang, Shih Ming

AU - Schie, Jen Tsong

AU - Tseng, Yung Zu

AU - Kuan, Peiliang

AU - Teng, Che Ming

AU - Lien, Wen Pin

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The mechanisms leading to formation of spontaneous echo contrast (SEC), a smoke-like echo on echocardiography, are still controversial. To further explore the clinical implications and factors related to SEC formation, the correlation among echocardiographic variables, hematologic parameters or platelet aggregability, and the occurrence of SEC was studied in 119 patients with chronic nonvalvular atrial fibrillation. There were 75 men and 44 women with a mean age of 65 ± 10 years (range 38-88). Left atrial SEC was detected in 39 patients (33%) by transesophageal echocardiography. Patients with history of systemic embolism were more frequently found to have left atrial SEC and left atrial thrombus by univariate analysis. Multivariate analysis showed that left atrial SEC (p < 0.001) was the only independent predictor of history of systemic embolism. Age, sex, left atrial or left ventricular dimension, left ventricular ejection fraction, antiplatelet or anticoagulant therapy and the percentage of lone atrial fibrillation were not significantly different between patients with and without left atrial SEC. Among the hematologic parameters, higher hematocrit was found in patients with left atrial SEC, while white blood cell and platelet counts were comparable in both groups. Platelet aggregability with different concentrations of inducers, adenosine diphosphate and collagen, was evaluated by the turbidimetric method in 15 patients with left atrial SEC and in 42 patients without left atrial SEC who were not receiving antiplatelet or anticoagulant therapy. No significant difference was found in platelet aggregability using four inducer concentrations between two groups of patients. It is therefore concluded that SEC formation is related to the hematocrit level in patients with nonvalvular atrial fibrillation, and the results also support the hypothesis that left atrial SEC comes from erythrocyte aggregation.

AB - The mechanisms leading to formation of spontaneous echo contrast (SEC), a smoke-like echo on echocardiography, are still controversial. To further explore the clinical implications and factors related to SEC formation, the correlation among echocardiographic variables, hematologic parameters or platelet aggregability, and the occurrence of SEC was studied in 119 patients with chronic nonvalvular atrial fibrillation. There were 75 men and 44 women with a mean age of 65 ± 10 years (range 38-88). Left atrial SEC was detected in 39 patients (33%) by transesophageal echocardiography. Patients with history of systemic embolism were more frequently found to have left atrial SEC and left atrial thrombus by univariate analysis. Multivariate analysis showed that left atrial SEC (p < 0.001) was the only independent predictor of history of systemic embolism. Age, sex, left atrial or left ventricular dimension, left ventricular ejection fraction, antiplatelet or anticoagulant therapy and the percentage of lone atrial fibrillation were not significantly different between patients with and without left atrial SEC. Among the hematologic parameters, higher hematocrit was found in patients with left atrial SEC, while white blood cell and platelet counts were comparable in both groups. Platelet aggregability with different concentrations of inducers, adenosine diphosphate and collagen, was evaluated by the turbidimetric method in 15 patients with left atrial SEC and in 42 patients without left atrial SEC who were not receiving antiplatelet or anticoagulant therapy. No significant difference was found in platelet aggregability using four inducer concentrations between two groups of patients. It is therefore concluded that SEC formation is related to the hematocrit level in patients with nonvalvular atrial fibrillation, and the results also support the hypothesis that left atrial SEC comes from erythrocyte aggregation.

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