Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients

Jann Tay Wang, Wang Huei Sheng, Chi Tai Fang, Yee Chun Chen, Jiun Ling Wang, Chong Jen Yu, Shan Chwen Chang, Pan Chyr Yang

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)


Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.

Original languageEnglish
Pages (from-to)818-824
Number of pages7
JournalEmerging infectious diseases
Issue number5
Publication statusPublished - 2004 May

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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