Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients

Jann Tay Wang, Wang Huei Sheng, Chi Tai Fang, Yee Chun Chen, Jiun-Ling Wang, Chong Jen Yu, Shan Chwen Chang, Pan Chyr Yang

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.

Original languageEnglish
Pages (from-to)818-824
Number of pages7
JournalEmerging infectious diseases
Volume10
Issue number5
DOIs
Publication statusPublished - 2004 Jan 1

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Severe Acute Respiratory Syndrome
C-Reactive Protein
Lymphopenia
Myalgia
Leukopenia
Creatine Kinase
Transaminases
Taiwan
L-Lactate Dehydrogenase
Cough
Thrombocytopenia
Dyspnea
Diarrhea
Pneumonia
Fever
Multivariate Analysis
Prospective Studies
Mortality

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Wang, Jann Tay ; Sheng, Wang Huei ; Fang, Chi Tai ; Chen, Yee Chun ; Wang, Jiun-Ling ; Yu, Chong Jen ; Chang, Shan Chwen ; Yang, Pan Chyr. / Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients. In: Emerging infectious diseases. 2004 ; Vol. 10, No. 5. pp. 818-824.
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Wang, JT, Sheng, WH, Fang, CT, Chen, YC, Wang, J-L, Yu, CJ, Chang, SC & Yang, PC 2004, 'Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients', Emerging infectious diseases, vol. 10, no. 5, pp. 818-824. https://doi.org/10.3201/eid1005.030640

Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients. / Wang, Jann Tay; Sheng, Wang Huei; Fang, Chi Tai; Chen, Yee Chun; Wang, Jiun-Ling; Yu, Chong Jen; Chang, Shan Chwen; Yang, Pan Chyr.

In: Emerging infectious diseases, Vol. 10, No. 5, 01.01.2004, p. 818-824.

Research output: Contribution to journalArticle

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