TY - JOUR
T1 - Clinical Outcomes in Diabetic Patients with Zinc Deficiency
T2 - A Multi-Institutional Population-Based Study
AU - Wu, Jheng Yan
AU - Wu, Yu Jou
AU - Liu, Mei Yuan
AU - Hsu, Wan Hsuan
AU - Tsai, Ya Wen
AU - Liu, Ting Hui
AU - Huang, Po Yu
AU - Chuang, Min Hsiang
AU - Lee, Mei Chuan
AU - Hung, Kuo Chuan
AU - Yu, Tsung
AU - Lin, Bing Han
AU - Liao, Kuang Ming
AU - Lai, Chih Cheng
N1 - Publisher Copyright:
© 2025 American Nutrition Association.
PY - 2025
Y1 - 2025
N2 - Objective: This study aimed to investigate the association between zinc deficiency (ZD) and the risks of all-cause mortality, major adverse cardiovascular events (MACEs), major adverse kidney events (MAKEs), and all-cause hospitalization in diabetic patients. Methods: This retrospective cohort study utilized the TriNetX research network to identify adult patients with diabetes mellitus (DM) between January 1, 2010, and August 31, 2024. Propensity score matching was used to match patients with serum zinc levels below 70 µg/dL (ZD group) to those with serum zinc levels between 70 and 120 µg/dL (control group). Results: Each group comprised 11,698 matched patients with balanced baseline characteristics. During the 1-year follow-up period, the ZD group exhibited significantly higher risks of all-cause mortality (hazard ratio [HR]: 1.788, 95% confidence interval [CI]: 1.591–2.009), MACEs (HR: 1.641, 95% CI: 1.278–2.105), and MAKEs (HR: 1.534, 95% CI: 1.293–1.821), as well as a higher risk of hospitalization (HR: 1.272, 95% CI: 1.216–1.330). Conclusion: Zinc deficiency in diabetic patients is associated with increased risks of all-cause mortality, MACEs, MAKEs, and all-cause hospitalization. These findings underscore the importance of assessing zinc status in the clinical management of patients with DM.
AB - Objective: This study aimed to investigate the association between zinc deficiency (ZD) and the risks of all-cause mortality, major adverse cardiovascular events (MACEs), major adverse kidney events (MAKEs), and all-cause hospitalization in diabetic patients. Methods: This retrospective cohort study utilized the TriNetX research network to identify adult patients with diabetes mellitus (DM) between January 1, 2010, and August 31, 2024. Propensity score matching was used to match patients with serum zinc levels below 70 µg/dL (ZD group) to those with serum zinc levels between 70 and 120 µg/dL (control group). Results: Each group comprised 11,698 matched patients with balanced baseline characteristics. During the 1-year follow-up period, the ZD group exhibited significantly higher risks of all-cause mortality (hazard ratio [HR]: 1.788, 95% confidence interval [CI]: 1.591–2.009), MACEs (HR: 1.641, 95% CI: 1.278–2.105), and MAKEs (HR: 1.534, 95% CI: 1.293–1.821), as well as a higher risk of hospitalization (HR: 1.272, 95% CI: 1.216–1.330). Conclusion: Zinc deficiency in diabetic patients is associated with increased risks of all-cause mortality, MACEs, MAKEs, and all-cause hospitalization. These findings underscore the importance of assessing zinc status in the clinical management of patients with DM.
UR - https://www.scopus.com/pages/publications/85217067762
UR - https://www.scopus.com/pages/publications/85217067762#tab=citedBy
U2 - 10.1080/27697061.2025.2461215
DO - 10.1080/27697061.2025.2461215
M3 - Article
C2 - 39908138
AN - SCOPUS:85217067762
SN - 2769-7061
VL - 44
SP - 521
EP - 528
JO - Journal of the American Nutrition Association
JF - Journal of the American Nutrition Association
IS - 6
ER -
