Clinical suppression of precocious puberty with cetrorelix after failed treatment with GnRH agoinst in a girl with gonadotrophin-independent precocious puberty

Meng Hsing Wu, Shio Jean Lin, Li Hsiang Wu, Yueh Chin Cheng, Yen Yin Chou, Hsien An Pan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This report presents the case of a 7-year-old girl with gonadotrophin-independent precocious puberty treated with cetrorelix [gonadotrophin-releasing hormone (GnRH) antagonist] after poor response to GnRH agonist therapy was observed in the endocrinology outpatient clinic. Uterine and ovarian morphology returned to within the normal prepubertal range after GnRH antagonist was injected subcutaneously. Vaginal bleeding stopped completely. The effects of GnRH antagonist treatment were comparable to those of GnRH agonist. The potential advantage of GnRH antagonists would be a clinically significant direct effect on the ovary, if it exists, and GnRH antagonists should be available for use in such children.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalReproductive BioMedicine Online
Volume11
Issue number1
DOIs
Publication statusPublished - 2005 Jul

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

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