Clinical ultrasound stimulating angiogenesis following drug-release from polymersomes on the ischemic zone for peripheral arterial occlusive disease

Chung-Dann Kan, Jieh-Neng Wang, Wei Peng Li, Shao Hsien Lin, Wei Ling Chen, Ya Ping Hsu, Chen-Sheng Yeh

Research output: Contribution to journalArticle

Abstract

Peripheral Arterial Occlusive Disease (PAOD) is an aging disease that affects the quality of life of many people by its intermittent claudication and critical limb ischemia presentations. Traditional treatment and management of PAOD are asking patients to make a life change and medication with antiplatelet, statins and cilostazol, which decrease the possibility of clot formation. Our strategy has employed a magnetic Fe 3 O 4 -PLGA polymersome to carry the cilostazol into the ischemic area by magnetic attraction following remote-control drug release through low-energy ultrasound exposure. In the animal studies, the cilostazol-loaded Fe 3 O 4 -PLGA polymersomes were injected and accumulated at ischemic leg through magnetic attraction. Then, using a clinical-use ultrasound machine the leg was irradiated to forward cilostazol release from the accumulated polymersomes. Dramatically, we found an observable result of bloody flux recovery in the leg after 7 days compared to the non-treated leg that showed no evidence of the blood recovery.

Original languageEnglish
Pages (from-to)2205-2213
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume14
Issue number7
DOIs
Publication statusPublished - 2018 Oct 1

Fingerprint

Arterial Occlusive Diseases
Peripheral Arterial Disease
Leg
Ultrasonics
Pharmaceutical Preparations
Recovery
Remote control
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Intermittent Claudication
Animals
Blood
Aging of materials
Fluxes
Ischemia
Extremities
Quality of Life
Drug Liberation
cilostazol
polylactic acid-polyglycolic acid copolymer
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

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title = "Clinical ultrasound stimulating angiogenesis following drug-release from polymersomes on the ischemic zone for peripheral arterial occlusive disease",
abstract = "Peripheral Arterial Occlusive Disease (PAOD) is an aging disease that affects the quality of life of many people by its intermittent claudication and critical limb ischemia presentations. Traditional treatment and management of PAOD are asking patients to make a life change and medication with antiplatelet, statins and cilostazol, which decrease the possibility of clot formation. Our strategy has employed a magnetic Fe 3 O 4 -PLGA polymersome to carry the cilostazol into the ischemic area by magnetic attraction following remote-control drug release through low-energy ultrasound exposure. In the animal studies, the cilostazol-loaded Fe 3 O 4 -PLGA polymersomes were injected and accumulated at ischemic leg through magnetic attraction. Then, using a clinical-use ultrasound machine the leg was irradiated to forward cilostazol release from the accumulated polymersomes. Dramatically, we found an observable result of bloody flux recovery in the leg after 7 days compared to the non-treated leg that showed no evidence of the blood recovery.",
author = "Chung-Dann Kan and Jieh-Neng Wang and Li, {Wei Peng} and Lin, {Shao Hsien} and Chen, {Wei Ling} and Hsu, {Ya Ping} and Chen-Sheng Yeh",
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AU - Kan, Chung-Dann

AU - Wang, Jieh-Neng

AU - Li, Wei Peng

AU - Lin, Shao Hsien

AU - Chen, Wei Ling

AU - Hsu, Ya Ping

AU - Yeh, Chen-Sheng

PY - 2018/10/1

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AB - Peripheral Arterial Occlusive Disease (PAOD) is an aging disease that affects the quality of life of many people by its intermittent claudication and critical limb ischemia presentations. Traditional treatment and management of PAOD are asking patients to make a life change and medication with antiplatelet, statins and cilostazol, which decrease the possibility of clot formation. Our strategy has employed a magnetic Fe 3 O 4 -PLGA polymersome to carry the cilostazol into the ischemic area by magnetic attraction following remote-control drug release through low-energy ultrasound exposure. In the animal studies, the cilostazol-loaded Fe 3 O 4 -PLGA polymersomes were injected and accumulated at ischemic leg through magnetic attraction. Then, using a clinical-use ultrasound machine the leg was irradiated to forward cilostazol release from the accumulated polymersomes. Dramatically, we found an observable result of bloody flux recovery in the leg after 7 days compared to the non-treated leg that showed no evidence of the blood recovery.

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