CMOS electrochemical measurement circuit for biomolecular detection

Wei Chiun Liu, Shao Te Wu, Bin Da Liu, Chia Ling Wei

Research output: Contribution to journalArticle

Abstract

This paper presents a three-electrode potentiostat transducer circuit for electrochemical sensing system designed for biomolecular detection. Melatonin has been found to be used as a significant index of potential breast cancer risk. The proposed chip automatically measures the redox current which depends on the concentration of melatonin in the analyte solution. Moreover, a current-to-time converter is designed to convert the sensed current into the proportional digitized time signal for back-end signal processing. Cyclic voltammetry and molecularly imprinted polymers were used in the experiments. The sensing electrodes were coated with a thin film imprinted with the target molecule. Fabricated in the TSMC CMOS 0.18 μm 1P6M technology, the proposed chip has a core chip size of 0.083 mm2 and a power consumption of 1.143 mW with a 1.8 V supply voltage. This chip can measure the sensed current from ±15 to ±1500 µA with a linearity of R2 = 0.999. In the cyclic voltammetry measurement, this chip has an error of less than 0.7%. The urine measurement results of the proposed chip were compared with that of enzyme-linked immune sorbent assay. Verified by melatonin concentration measurement, the proposed chip with high sensitivity demonstrates the feasibility of melatonin concentration detection, which contributes to the examination of breast cancer.

Original languageEnglish
Pages (from-to)1467-1486
Number of pages20
JournalInternational Journal of Electronics
Volume105
Issue number9
DOIs
Publication statusPublished - 2018 Sep 2

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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