Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder

Hong-Lin Cheng, Hsiao-Sheng Liu, Yih-Jyh Lin, Helen H.W Chen, P. Y. Hsu, T. Y. Chang, Chung-Liang Ho, T. S. Tzai, Nan-Haw Chow

Research output: Contribution to journalArticle

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Abstract

Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic significance of RON and/or c-met protein (MET) expression was analysed in a bladder cancer cohort (n = 183). There was no evidence of mutation in the kinase domain of RON. Overexpression of RON using an inducible Tet-off system induced increased cell proliferation, motility, and antiapoptosis. Immunohistochemical analysis showed that RON was overexpressed in 60 cases (32.8%) of primary tumours, with 14 (23.3%) showing a high level of expression. Recepteur d'Origine Nantais expression was positively associated with histological grading, larger size, nonpapillary contour, and tumour stage (all P < 0.01). In addition, MET was overexpressed in 82 cases (44.8%). Co-expressed RON and MET was significantly associated with decreased overall survival (P = 0.005) or metastasis-free survival (P = 0.01) in 35 cases (19.1%). Recepteur d'Origine Nantais-associated signalling may play an important role in the progression of human bladder cancer. Evaluation of RON and MET expression status may identify a subset of bladder-cancer patients who require more intensive treatment.

Original languageEnglish
Pages (from-to)1906-1914
Number of pages9
JournalBritish Journal of Cancer
Volume92
Issue number10
DOIs
Publication statusPublished - 2005 May 23

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Transitional Cell Carcinoma
Urinary Bladder
Urinary Bladder Neoplasms
Proto-Oncogene Proteins c-met
RON protein
Neoplasms
Survival
Proto-Oncogenes
Cell Movement
Phosphotransferases
Cell Proliferation
Neoplasm Metastasis
Cell Line

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder",
abstract = "Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic significance of RON and/or c-met protein (MET) expression was analysed in a bladder cancer cohort (n = 183). There was no evidence of mutation in the kinase domain of RON. Overexpression of RON using an inducible Tet-off system induced increased cell proliferation, motility, and antiapoptosis. Immunohistochemical analysis showed that RON was overexpressed in 60 cases (32.8{\%}) of primary tumours, with 14 (23.3{\%}) showing a high level of expression. Recepteur d'Origine Nantais expression was positively associated with histological grading, larger size, nonpapillary contour, and tumour stage (all P < 0.01). In addition, MET was overexpressed in 82 cases (44.8{\%}). Co-expressed RON and MET was significantly associated with decreased overall survival (P = 0.005) or metastasis-free survival (P = 0.01) in 35 cases (19.1{\%}). Recepteur d'Origine Nantais-associated signalling may play an important role in the progression of human bladder cancer. Evaluation of RON and MET expression status may identify a subset of bladder-cancer patients who require more intensive treatment.",
author = "Hong-Lin Cheng and Hsiao-Sheng Liu and Yih-Jyh Lin and Chen, {Helen H.W} and Hsu, {P. Y.} and Chang, {T. Y.} and Chung-Liang Ho and Tzai, {T. S.} and Nan-Haw Chow",
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Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder. / Cheng, Hong-Lin; Liu, Hsiao-Sheng; Lin, Yih-Jyh; Chen, Helen H.W; Hsu, P. Y.; Chang, T. Y.; Ho, Chung-Liang; Tzai, T. S.; Chow, Nan-Haw.

In: British Journal of Cancer, Vol. 92, No. 10, 23.05.2005, p. 1906-1914.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder

AU - Cheng, Hong-Lin

AU - Liu, Hsiao-Sheng

AU - Lin, Yih-Jyh

AU - Chen, Helen H.W

AU - Hsu, P. Y.

AU - Chang, T. Y.

AU - Ho, Chung-Liang

AU - Tzai, T. S.

AU - Chow, Nan-Haw

PY - 2005/5/23

Y1 - 2005/5/23

N2 - Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic significance of RON and/or c-met protein (MET) expression was analysed in a bladder cancer cohort (n = 183). There was no evidence of mutation in the kinase domain of RON. Overexpression of RON using an inducible Tet-off system induced increased cell proliferation, motility, and antiapoptosis. Immunohistochemical analysis showed that RON was overexpressed in 60 cases (32.8%) of primary tumours, with 14 (23.3%) showing a high level of expression. Recepteur d'Origine Nantais expression was positively associated with histological grading, larger size, nonpapillary contour, and tumour stage (all P < 0.01). In addition, MET was overexpressed in 82 cases (44.8%). Co-expressed RON and MET was significantly associated with decreased overall survival (P = 0.005) or metastasis-free survival (P = 0.01) in 35 cases (19.1%). Recepteur d'Origine Nantais-associated signalling may play an important role in the progression of human bladder cancer. Evaluation of RON and MET expression status may identify a subset of bladder-cancer patients who require more intensive treatment.

AB - Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic significance of RON and/or c-met protein (MET) expression was analysed in a bladder cancer cohort (n = 183). There was no evidence of mutation in the kinase domain of RON. Overexpression of RON using an inducible Tet-off system induced increased cell proliferation, motility, and antiapoptosis. Immunohistochemical analysis showed that RON was overexpressed in 60 cases (32.8%) of primary tumours, with 14 (23.3%) showing a high level of expression. Recepteur d'Origine Nantais expression was positively associated with histological grading, larger size, nonpapillary contour, and tumour stage (all P < 0.01). In addition, MET was overexpressed in 82 cases (44.8%). Co-expressed RON and MET was significantly associated with decreased overall survival (P = 0.005) or metastasis-free survival (P = 0.01) in 35 cases (19.1%). Recepteur d'Origine Nantais-associated signalling may play an important role in the progression of human bladder cancer. Evaluation of RON and MET expression status may identify a subset of bladder-cancer patients who require more intensive treatment.

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