CO2 Delivery to Accelerate Incisional Wound Healing Following Single Irradiation of Near-Infrared Lamp on the Coordinated Colloids

Wei Peng Li, Chia Hao Su, Sheng Jung Wang, Fu Ju Tsai, Chun Ting Chang, Min Chiao Liao, Chun Chieh Yu, Thi Tuong Vi Tran, Chaw Ning Lee, Wen Tai Chiu, Tak Wah Wong, Chen Sheng Yeh

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Traditional wound care methods include wound infection control, adequate nutritional supplements, education of changing position every 2-3 h to avoid tissue hypoxia, vacuum assistant closure, debridement, skin graft, and tissue flap. Electric current stimulation, ultrasound, laser, and hydrotherapy have emerged as adjuvant therapies. However, most, if not all, of these therapies are expensive, and the treatment results are variable. The development of the active methods to improve wound healing is mandatory. CO2 administration has been known to improve microcirculation and local oxygen supply that are beneficial to wound healing. Here, the metal ion-ligand coordination nanoarchitecture was designed to reveal NIR light-induced CO2 generation for wound healing. The administration simply topically dropped the colloidal solution on the incisional wound, followed by exposure of near-infrared (NIR) lamp to yield CO2, resulting in the observation of the accelerated wound healing.

Original languageEnglish
Pages (from-to)5826-5835
Number of pages10
JournalACS nano
Volume11
Issue number6
DOIs
Publication statusPublished - 2017 Jun 27

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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