Cocaine and 5-HT1B Receptor-Induced Long-Term Depression

C. C. Huang, C. C. Chen, Kuei-Sen Hsu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug seeking, loss of control in limiting intake, and emergence of negative emotional states. Although the neural and molecular mechanisms underlying cocaine addiction are not yet completely understood, there is now much evidence that cocaine addiction and natural reward-related memory may share similar neural circuits and molecular mechanisms. Recent studies demonstrate that cocaine elicits or modifies synaptic plasticity of glutamatergic transmission in the mesocorticolimbic dopamine system, which is the central component of the brain's reward processing. Despite the promising research on the brain dopaminergic pathways, recent research also highlights the involvement of serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and particularly 5-HT 1B receptors in the behavioral effects of cocaine. Here, we summarize experimental characterization of the role of 5-HT 1B receptors in mediating the neurobiological effects of cocaine and discuss how cocaine impairs the induction of 5-HT 1B receptor-induced long-term depression in the nucleus accumbens.

Original languageEnglish
Title of host publicationThe Neuroscience of Cocaine
Subtitle of host publicationMechanisms and Treatment
PublisherElsevier Inc.
Pages439-447
Number of pages9
ISBN (Electronic)9780128037928
ISBN (Print)9780128037508
DOIs
Publication statusPublished - 2017 May 16

Fingerprint

Receptor, Serotonin, 5-HT1B
Cocaine
Cocaine-Related Disorders
Depression
Reward
Serotonin
Neuronal Plasticity
Nucleus Accumbens
Brain
Research
Synaptic Transmission
Dopamine
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Psychology(all)

Cite this

Huang, C. C., Chen, C. C., & Hsu, K-S. (2017). Cocaine and 5-HT1B Receptor-Induced Long-Term Depression. In The Neuroscience of Cocaine: Mechanisms and Treatment (pp. 439-447). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803750-8.00044-0
Huang, C. C. ; Chen, C. C. ; Hsu, Kuei-Sen. / Cocaine and 5-HT1B Receptor-Induced Long-Term Depression. The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc., 2017. pp. 439-447
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Huang, CC, Chen, CC & Hsu, K-S 2017, Cocaine and 5-HT1B Receptor-Induced Long-Term Depression. in The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc., pp. 439-447. https://doi.org/10.1016/B978-0-12-803750-8.00044-0

Cocaine and 5-HT1B Receptor-Induced Long-Term Depression. / Huang, C. C.; Chen, C. C.; Hsu, Kuei-Sen.

The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc., 2017. p. 439-447.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Huang CC, Chen CC, Hsu K-S. Cocaine and 5-HT1B Receptor-Induced Long-Term Depression. In The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc. 2017. p. 439-447 https://doi.org/10.1016/B978-0-12-803750-8.00044-0